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YKL-5-124

Name: YKL-5-124
Brand: TargetMol
SKU: T22461
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T22461Cas No. 1957203-01-8

YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays biochemical and cellular selectivity for CDK7 over CDK12/13.

YKL-5-124

🥰Excellent

Purity: 99.36%

Catalog No. T22461Cas No. 1957203-01-8

Pack Size	Price	Availability
1 mg	$97	In Stock
2 mg	$137	In Stock
5 mg	$198	In Stock
10 mg	$359	In Stock
25 mg	$577	In Stock
50 mg	$823	In Stock
100 mg	$1,090	In Stock
1 mL x 10 mM (in DMSO)	$237	In Stock

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Purity:99.36%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays biochemical and cellular selectivity for CDK7 over CDK12/13.
Targets&IC50	CDK9:3020 nM, CDK2:1300 nM, CDK7-CyclinH-MAT1:9.7 nM, CDK7:53.5 nM

Chemical Properties

Molecular Weight	515.61
Formula	C₂₈H₃₃N₇O₃
Cas No.	1957203-01-8
Smiles	CN(C)C[C@@H](NC(=O)N1Cc2c(NC(=O)c3ccc(NC(=O)C=C)cc3)n[nH]c2C1(C)C)c1ccccc1
Relative Density.	1.284 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 220 mg/mL (426.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9395 mL	9.6973 mL	19.3945 mL	96.9725 mL
5 mM	0.3879 mL	1.9395 mL	3.8789 mL	19.3945 mL
10 mM	0.1939 mL	0.9697 mL	1.9395 mL	9.6973 mL
20 mM	0.0970 mL	0.4849 mL	0.9697 mL	4.8486 mL
50 mM	0.0388 mL	0.1939 mL	0.3879 mL	1.9395 mL
100 mM	0.0194 mL	0.0970 mL	0.1939 mL	0.9697 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc