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Anti-Cathepsin D Polyclonal Antibody 2
Catalog No. TMAB-03683 Copy Product Info
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Anti-Cathepsin D Polyclonal Antibody 2 is a Rabbit antibody targeting Cathepsin D. Anti-Cathepsin D Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF.
Anti-Cathepsin D Polyclonal Antibody 2
Copy Product Info🥰Excellent
Catalog No. TMAB-03683
Anti-Cathepsin D Polyclonal Antibody 2 is a Rabbit antibody targeting Cathepsin D. Anti-Cathepsin D Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF.
Anti-Cathepsin D Polyclonal Antibody 2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-Cathepsin D Polyclonal Antibody 2 is a Rabbit antibody targeting Cathepsin D. Anti-Cathepsin D Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Rat) |
| Verified Activity | 1. Sample: Cerebrum (Mouse) Lysate at 40 μg Primary: Anti-Cathepsin D (TMAB-03683) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 45 kD Observed band size: 45 kD 2. Sample: AortA (Mouse) Lysate at 40 μg Primary: Anti-Cathepsin D (TMAB-03683) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 45 kD Observed band size: 45 kD 3. Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (Cathepsin D) Polyclonal Antibody, Unconjugated (TMAB-03683) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Tissue Specificity | Expressed in the aorta extrcellular space (at protein level). |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer and possibly Alzheimer's disease. |
| Immunogen | KLH conjugated synthetic peptide: mouse Cathepsin D heavy chain |
| Antigen Species | Mouse |
| Gene Name | CTSD |
| Gene ID | |
| Protein Name | Cathepsin D |
| Uniprot ID | |
| Function | Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. |
| Molecular Weight | Theoretical: 45 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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