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Ciprofloxacin monohydrochloride
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Catalog No. T0250Cas No. 93107-08-5
Alias Ciprofloxacin hydrochloride, Ciprofloxacin HCl, Bay-09867 (hydrochloride)
Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.
Ciprofloxacin monohydrochloride
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Purity: 99.73%
Catalog No. T0250Alias Ciprofloxacin hydrochloride, Ciprofloxacin HCl, Bay-09867 (hydrochloride)Cas No. 93107-08-5
Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 g | $35 | - | In Stock | |
| 5 g | $73 | - | In Stock | |
| 10 g | $106 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.73%
Appearance:Solid
Color:White
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Product Introduction
Ciprofloxacin monohydrochloride AI Summary
Ciprofloxacin monohydrochloride exhibits broad-spectrum antibacterial activity against a variety of gram-positive and gram-negative bacteria, including drug-resistant strains. It is effective against notable pathogens such as Staphylococcus aureus, Streptococcus species, Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, Listeria monocytogenes, Klebsiella pneumoniae, Klebsiella oxytoca, Bacillus anthracis, and Salmonella enterica, with Minimum Inhibitory Concentrations (MIC) ranging from 0.05 to 6.25 µg/mL. It also shows significant antifungal activity, particularly against Candida albicans. In vitro studies reveal that Ciprofloxacin monohydrochloride inhibits Escherichia coli DNA gyrase with an IC50 of 0.2-0.24 µg/mL and demonstrates inhibitory effects on DNA, RNA, and protein synthesis in bacterial cells. It exhibits oral bioavailability in rats at 16% and shows favorable pharmacokinetic properties, including moderate oral bioavailability and good plasma exposure levels. Additionally, Ciprofloxacin monohydrochloride has been noted for its activity in blocking Ebola virus entry and inhibiting human tyrosyl-DNA phosphodiesterase 1 (TDP1). In vivo studies indicate its efficacy against bacterial infections following subcutaneous and oral administrations, highlighting its therapeutic potential..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline. |
| Synonyms | Ciprofloxacin hydrochloride, Ciprofloxacin HCl, Bay-09867 (hydrochloride) |
| Molecular Weight | 367.80 |
| Formula | C17H18FN3O3·HCl |
| Cas No. | 93107-08-5 |
| Smiles | Cl.OC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=O |
| Relative Density. | no data available |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 4.23 mg/mL (11.5 mM), Sonication is recommended.  H2O: 30.03 mg/mL (81.65 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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