Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zanolimumab (Anti-Human CD4 Recombinant Antibody) is a fully human monoclonal antibody that targets the CD4 molecule and effectively inhibits T-cell receptor (TCR) signal transduction. It is used in the research of rheumatoid arthritis, psoriasis, melanoma, cutaneous, and peripheral T-cell lymphoma [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | Inquiry | |
5 mg | Inquiry | Inquiry |
Description | Zanolimumab (Anti-Human CD4 Recombinant Antibody) is a fully human monoclonal antibody that targets the CD4 molecule and effectively inhibits T-cell receptor (TCR) signal transduction. It is used in the research of rheumatoid arthritis, psoriasis, melanoma, cutaneous, and peripheral T-cell lymphoma [1]. |
In vitro | Zanolimumab, at concentrations of 10 and 100 ng/mL, effectively induces cytotoxicity in CD4+ T cells, demonstrating enhanced activity on the CD45RO+ subset compared to the CD45RA+ subset. Additionally, within a range of 1-10,000 ng/mL, the compound dose-dependently and through its Fc region, decreases CD4 expression on both purified primary CD4+ T cells and SUP-T1 T cells. Furthermore, Zanolimumab potently suppresses T-cell proliferation initiated by T-cell receptor (TCR) stimulation, as observed with both tetanus toxin and anti-CD3 challenges, and inhibits TCR signal transduction within a 0-30 minute timeframe. |
Synonyms | Anti-Human CD4 Recombinant Antibody |
Molecular Weight | N/A |
CAS No. | 652153-01-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Zanolimumab 652153-01-0 Anti-Human CD4 Recombinant Antibody inhibitor inhibit