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Zanolimumab (Synonyms: Anti-Human CD4 Recombinant Antibody)
Catalog No. T80744 Copy Product Info
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Zanolimumab is a humanised monoclonal antibody targeting CD4, exhibiting cytotoxic and antiproliferative properties. By binding to the CD4 molecule and blocking T cell receptor (TCR) signalling, it is used in the treatment of autoimmune diseases such as rheumatoid arthritis, psoriasis, and T-cell lymphoma.
Zanolimumab
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Catalog No. T80744
Synonyms Anti-Human CD4 Recombinant Antibody
Zanolimumab is a humanised monoclonal antibody targeting CD4, exhibiting cytotoxic and antiproliferative properties. By binding to the CD4 molecule and blocking T cell receptor (TCR) signalling, it is used in the treatment of autoimmune diseases such as rheumatoid arthritis, psoriasis, and T-cell lymphoma.
Zanolimumab
Cas No. 652153-01-0
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | - | In Stock | |
| 5 mg | $619 | - | In Stock | |
| 10 mg | $993 | - | In Stock | |
| 25 mg | $1,470 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:97.2% (SDS-PAGE); 97.1% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Zanolimumab is a humanised monoclonal antibody targeting CD4, exhibiting cytotoxic and antiproliferative properties. By binding to the CD4 molecule and blocking T cell receptor (TCR) signalling, it is used in the treatment of autoimmune diseases such as rheumatoid arthritis, psoriasis, and T-cell lymphoma. |
| In vitro | Methods: To evaluate the ability of Zanolimumab to induce antibody-dependent cell-mediated cytotoxicity (ADCC) via natural killer (NK) cells, we conducted in vitro cytotoxicity assays using NK cells as effector cells and CD4⁺ T cells as target cells. Results: We found that Zanolimumab was highly effective in promoting the killing of CD4⁺ T cells, inducing significant specific lysis at a concentration of 10 ng/mL. Moreover, at both 10 and 100 ng/mL, Zanolimumab showed a stronger cytotoxic effect on the CD45RO⁺ subset than on the CD45RA⁺ subset.[1] |
| Synonyms | Anti-Human CD4 Recombinant Antibody |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | CD4/LEU3 |
| Molecular Weight | 143.81 kDa |
| Cas No. | 652153-01-0 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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