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Zanolimumab (Synonyms: Anti-Human CD4 Recombinant Antibody)
Catalog No. T80744 Copy Product Info
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Zanolimumab is a humanised monoclonal antibody targeting CD4, exhibiting cytotoxic and antiproliferative properties. By binding to the CD4 molecule and blocking T cell receptor (TCR) signalling, it is used in the treatment of autoimmune diseases such as rheumatoid arthritis, psoriasis, and T-cell lymphoma.
Zanolimumab
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Catalog No. T80744
Synonyms Anti-Human CD4 Recombinant Antibody
Zanolimumab is a humanised monoclonal antibody targeting CD4, exhibiting cytotoxic and antiproliferative properties. By binding to the CD4 molecule and blocking T cell receptor (TCR) signalling, it is used in the treatment of autoimmune diseases such as rheumatoid arthritis, psoriasis, and T-cell lymphoma.
Zanolimumab
Cas No. 652153-01-0
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | - | In Stock | |
| 5 mg | $619 | - | In Stock | |
| 10 mg | $993 | - | In Stock | |
| 25 mg | $1,470 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:97.2% (SDS-PAGE); 97.1% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Zanolimumab is a humanised monoclonal antibody targeting CD4, exhibiting cytotoxic and antiproliferative properties. By binding to the CD4 molecule and blocking T cell receptor (TCR) signalling, it is used in the treatment of autoimmune diseases such as rheumatoid arthritis, psoriasis, and T-cell lymphoma. |
| In vitro | Methods: To evaluate the ability of Zanolimumab to induce antibody-dependent cell-mediated cytotoxicity (ADCC) via natural killer (NK) cells, we conducted in vitro cytotoxicity assays using NK cells as effector cells and CD4⁺ T cells as target cells. Results: We found that Zanolimumab was highly effective in promoting the killing of CD4⁺ T cells, inducing significant specific lysis at a concentration of 10 ng/mL. Moreover, at both 10 and 100 ng/mL, Zanolimumab showed a stronger cytotoxic effect on the CD45RO⁺ subset than on the CD45RA⁺ subset.[1] |
| Synonyms | Anti-Human CD4 Recombinant Antibody |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | CD4/LEU3 |
| Molecular Weight | 143.81 kDa |
| Cas No. | 652153-01-0 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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