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Ifebemtinib FA

Catalog No. T64167L

Synonyms: BI-853520 FA（1227948-82-4 Free base)

Ifebemtinib FA (BI-853520 FA) is an orally active and potent inhibitor of adhesion patch kinase (FAK) with anticancer and antiproliferative activity for the study of ovarian and lung cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ifebemtinib FA, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 163.00
5 mg	In stock	$ 413.00
10 mg	In stock	$ 690.00
25 mg	In stock	$ 1,290.00
50 mg	In stock	$ 1,730.00
100 mg	In stock	$ 2,330.00

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Purity: 99.44%

Purity: 99.30%

Purity: 98.40%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ifebemtinib FA (BI-853520 FA) is an orally active and potent inhibitor of adhesion patch kinase (FAK) with anticancer and antiproliferative activity for the study of ovarian and lung cancer.
Targets&IC50	FER:900 nM, FES:1040 nM, FAK:1 nM
In vitro	The compound Ifebemtinib FA (BI-853520 FA) inhibits cancer cell growth at concentrations ranging from 0 to 3 μM for 2 hours[2]. Repression of tumor cell proliferation and invasion in 3D culture is observed with Ifebemtinib FA at concentrations from 0 to 30 μM for 4-6 days[1]. Additionally, Ifebemtinib FA represses Y397-FAK autophosphorylation at concentrations ranging from 0 to 10 μM for 24 hours, and at a concentration of 0.1 μM for 96 hours, Ifebemtinib FA demonstrates a fast and potent inhibition of FAK in this highly metastatic murine breast cancer cell line[3].
In vivo	The oral gavage treatment of Ifebemtinib FA (BI-853520 FA) at a dose of 50 mg/kg once daily for 0-8 weeks significantly suppresses the primary tumor growth of all three cell lines in vivo[3].

Synonyms	BI-853520 FA（1227948-82-4 Free base)
Molecular Weight	634.58
Formula	C29H30F4N6O6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ulrich A Hirt, et al. Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype. Oncogenesis. 2018 Feb 23;7(2):21. 2. Stefanie Tiede, et al. The FAK inhibitor BI 853520 exerts anti-tumor effects in breast cancer. Oncogenesis. 2018 Sep 20;7(9):73.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ifebemtinib FA Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors FAK BI853520FA（1227948824Freebase) BI-853520 FA（1227948-82-4 Free base) inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.