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BiP inducer X

Name: BiP inducer X
Brand: TargetMol
SKU: T30480
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T30480Cas No. 101714-41-4

Alias BIX

BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.

BiP inducer X

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Purity: 98.54%

Catalog No. T30480Alias BIXCas No. 101714-41-4

BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$128	In Stock	In Stock
50 mg	$222	In Stock	In Stock
100 mg	$372	In Stock	In Stock
200 mg	$549	-	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.54%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.
In vitro	Pretreatment of BiP inducer X (5 μM; 12 hours) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4. In SK-N-SH cells, BiP inducer X (5 μM; 0-12 hours) increases BiP protein and is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway[1].
In vivo	In male adult ddY mice, BiP inducer X (20 μg) reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion. BiP inducer X reduces the insults due to cerebral infarction[1].
Synonyms	BIX

Chemical Properties

Molecular Weight	209.22
Formula	C₉H₇NO₃S
Cas No.	101714-41-4
Smiles	Oc1ccc(cc1O)C(=O)CSC#N
Relative Density.	1.476 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (215.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 2 mg/mL (9.56 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7797 mL	23.8983 mL	47.7966 mL	238.9829 mL
5 mM	0.9559 mL	4.7797 mL	9.5593 mL	47.7966 mL
10 mM	0.4780 mL	2.3898 mL	4.7797 mL	23.8983 mL
20 mM	0.2390 mL	1.1949 mL	2.3898 mL	11.9491 mL
50 mM	0.0956 mL	0.4780 mL	0.9559 mL	4.7797 mL
100 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3898 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc