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Anti-RNF146 Polyclonal Antibody
😃Good
Catalog No. TMAB-01623
Alias RP3 351K20.1, RNF 146, RN146, RING finger protein 146, E3 ubiquitin-protein ligase rnf146, DKFZP434O1427, dJ351K20.1, Dactylidin
Anti-RNF146 Polyclonal Antibody is a Rabbit antibody targeting RNF146. Anti-RNF146 Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB.
Anti-RNF146 Polyclonal Antibody
Anti-RNF146 Polyclonal Antibody
😃Good
Catalog No. TMAB-01623Alias RP3 351K20.1, RNF 146, RN146, RING finger protein 146, E3 ubiquitin-protein ligase rnf146, DKFZP434O1427, dJ351K20.1, Dactylidin
Anti-RNF146 Polyclonal Antibody is a Rabbit antibody targeting RNF146. Anti-RNF146 Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-RNF146 Polyclonal Antibody is a Rabbit antibody targeting RNF146. Anti-RNF146 Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB. |
| Synonyms | RP3 351K20.1, RNF 146, RN146, RING finger protein 146, E3 ubiquitin-protein ligase rnf146, DKFZP434O1427, dJ351K20.1, Dactylidin |
| Ig Type | IgG |
| Reactivity | (predicted:Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser-induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding. |
| Tissue Specificity | Ubiquitously expressed. Up-regulated in brains from patients with Alzheimer disease. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF146 (RING finger protein 146), also known as Dactylidin, is a 359 amino acid protein that contains one RING-type zinc finger and one WWE domain. Via its RING-type zinc finger, RNF146 may play a role in transcriptional regulation and protein degradation events. Defects in the gene encoding RNF146 are associated with Alzheimer's disease (AD) and may lead to a higher risk of breast cancer. Two isoforms of RNF146 exist due to alternative splicing events. |
| Immunogen | KLH conjugated synthetic peptide: human RNF146 |
| Antigen Species | Human |
| Gene Name | RNF146 |
| Gene ID | |
| Protein Name | E3 ubiquitin-protein ligase RNF146 |
| Uniprot ID | |
| Biology Area | Alzheimer's disease |
| Function | E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination. |
| Molecular Weight | Theoretical: 39 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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