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Anti-RNF146 Polyclonal Antibody
😃Good
Catalog No. TMAB-01623
Alias RP3 351K20.1, RNF 146, RN146, RING finger protein 146, E3 ubiquitin-protein ligase rnf146, DKFZP434O1427, dJ351K20.1, Dactylidin
Anti-RNF146 Polyclonal Antibody is a Rabbit antibody targeting RNF146. Anti-RNF146 Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB.
Anti-RNF146 Polyclonal Antibody
Anti-RNF146 Polyclonal Antibody
😃Good
Catalog No. TMAB-01623Alias RP3 351K20.1, RNF 146, RN146, RING finger protein 146, E3 ubiquitin-protein ligase rnf146, DKFZP434O1427, dJ351K20.1, Dactylidin
Anti-RNF146 Polyclonal Antibody is a Rabbit antibody targeting RNF146. Anti-RNF146 Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-RNF146 Polyclonal Antibody is a Rabbit antibody targeting RNF146. Anti-RNF146 Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB. |
| Synonyms | RP3 351K20.1, RNF 146, RN146, RING finger protein 146, E3 ubiquitin-protein ligase rnf146, DKFZP434O1427, dJ351K20.1, Dactylidin |
| Ig Type | IgG |
| Reactivity | (predicted:Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser-induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding. |
| Tissue Specificity | Ubiquitously expressed. Up-regulated in brains from patients with Alzheimer disease. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Immunogen | KLH conjugated synthetic peptide: human RNF146 |
| Antigen Species | Human |
| Gene Name | RNF146 |
| Gene ID | |
| Protein Name | E3 ubiquitin-protein ligase RNF146 |
| Uniprot ID | |
| Biology Area | Alzheimer's disease |
| Function | E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination. |
| Molecular Weight | Theoretical: 39 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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