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Anti-SMAD4 Antibody (7P892)
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Catalog No. TMAH-01109
Alias SMAD4, SMAD Family Member 4, SMAD 4, Mothers Against DPP Homolog 4, Mothers Against Decapentaplegic Homolog 4, MADH4, MAD Homolog 4, hSMAD4, DPC4, Deletion Target in Pancreatic Carcinoma 4
Anti-SMAD4 Antibody (7P892) is an antibody targeting SMAD4. Anti-SMAD4 Antibody (7P892) can be used in ELISA, WB.
Anti-SMAD4 Antibody (7P892)
Anti-SMAD4 Antibody (7P892)
😃Good
Catalog No. TMAH-01109Alias SMAD4, SMAD Family Member 4, SMAD 4, Mothers Against DPP Homolog 4, Mothers Against Decapentaplegic Homolog 4, MADH4, MAD Homolog 4, hSMAD4, DPC4, Deletion Target in Pancreatic Carcinoma 4
Anti-SMAD4 Antibody (7P892) is an antibody targeting SMAD4. Anti-SMAD4 Antibody (7P892) can be used in ELISA, WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Monoclonal Application: ELISA, WB Reactivity: Human |
| Alias | SMAD4, SMAD Family Member 4, SMAD 4, Mothers Against DPP Homolog 4, Mothers Against Decapentaplegic Homolog 4, MADH4, MAD Homolog 4, hSMAD4, DPC4, Deletion Target in Pancreatic Carcinoma 4 |
| Ig Type | Rabbit IgG |
| Clone | 7P892 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate, MCF-7 whole cell lysate -All lanes: SMAD4 antibody at 1:500 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 61 kDa -Observed band size: 55-72 kDa |
| Application | ELISA, WB |
| Recommended Dose | WB:1:500-1:2000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Nucleus. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human SMAD4 |
| Antigen Species | Human |
| Gene ID | 4089 |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling, Cancer, Cardiovascular, Metabolism, Signal transduction, Stem cells |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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