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MI-538

Name: MI-538
Brand: TargetMol
SKU: T16072
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16072Cas No. 1857417-10-7

MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM).

MI-538

🥰Excellent

Purity: 99.8%

Catalog No. T16072Cas No. 1857417-10-7

MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM).

Pack Size	Price	Availability
1 mg	$58	In Stock
5 mg	$118	In Stock
10 mg	$198	In Stock
25 mg	$375	In Stock
50 mg	$563	In Stock
100 mg	$768	In Stock
1 mL x 10 mM (in DMSO)	$148	In Stock

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Batch Information

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Purity:99.8%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM).
Targets&IC50	Menin-MLL:21 nM , Menin:6.5 nM(Kd)
In vitro	Treatment with MI-538 results in strong down regulation of expression of Hoxa9 and Meis1 genes. About 100 nM 27 was sufficient to reduce by ~50% Hoxa9 expression in MLL-AF9 cells, and even more pronounced effect was seen on Meis1 expression.
In vivo	Treatment with MI-538 leads to an approximately 80% reduction in MV4;11 tumor volume, with minimal toxicity, evidenced by less than a 10% decrease in body weight.

Chemical Properties

Molecular Weight	566.6
Formula	C₂₇H₂₅F₃N₈OS
Cas No.	1857417-10-7
Smiles	Oc1cc2n(Cc3cn[nH]c3)c(cc2cc1CN1CCC(CC1)Nc1ncnc2sc(CC(F)(F)F)cc12)C#N
Relative Density.	1.56 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (167.67 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (17.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7649 mL	8.8246 mL	17.6491 mL	88.2457 mL
5 mM	0.3530 mL	1.7649 mL	3.5298 mL	17.6491 mL
10 mM	0.1765 mL	0.8825 mL	1.7649 mL	8.8246 mL
20 mM	0.0882 mL	0.4412 mL	0.8825 mL	4.4123 mL
50 mM	0.0353 mL	0.1765 mL	0.3530 mL	1.7649 mL
100 mM	0.0176 mL	0.0882 mL	0.1765 mL	0.8825 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc