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M4284

Name: M4284
Brand: TargetMol
SKU: T7777
Price: 113 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7777Cas No. 1373346-85-0

Alias M 4284

M4284 (M 4284) is a selective and orally active biphenyl mannoside FimH antagonist.

M4284

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Purity: 97.43%

Catalog No. T7777Alias M 4284Cas No. 1373346-85-0

M4284 (M 4284) is a selective and orally active biphenyl mannoside FimH antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$113	In Stock	In Stock
5 mg	$283	In Stock	In Stock
10 mg	$455	In Stock	In Stock
25 mg	$753	In Stock	In Stock
50 mg	$1,060	In Stock	In Stock
100 mg	$1,430	In Stock	In Stock
500 mg	$2,860	-	In Stock
1 mL x 10 mM (in DMSO)	$286	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.43%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

M4284 AI Summary

M4284 demonstrates remarkable bioactivity and pharmacokinetic properties. It shows a high ratio of drug uptake in mouse plasma to urine at both 50 mg/kg and 100 mg/kg doses after 6 hours, and maintains a urine level greater than 10 mM when administered orally at 50 mg/kg for 6 hours. The compound exhibits potent antibacterial activity against Escherichia coli K-12 ATCC 25404 with an IC50 value of 73.0 nM, and effectively inhibits Escherichia coli UTI89 FimH-mediated hemagglutination of human red blood cells with an EC>90 of 16.0 nM. In a chronic cystitis model, M4284 significantly reduces bacterial burden in the urinary bladder at 50 mg/kg doses. Furthermore, it shows a long half-life in plasma, gut fluid, and liver microsomes, all exceeding 2.0 hours. The compound also inhibits biofilm formation by Escherichia coli UTI89, with a urine to IC50 ratio of 10.0. Additionally, it has a binding affinity to biotinylated Escherichia coli FimH-lectin domain with a melting temperature of 75.76 degrees Celsius, although it has low effective permeability as indicated by a log Pe of -8.46 cm²/sec in the PAMPA assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	M4284 (M 4284) is a selective and orally active biphenyl mannoside FimH antagonist.
Synonyms	M 4284

Chemical Properties

Molecular Weight	460.48
Formula	C₂₃H₂₈N₂O₈
Cas No.	1373346-85-0
Smiles	CNC(=O)c1cc(cc(c1)-c1ccc(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O)c(C)c1)C(=O)NC
Relative Density.	1.359 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (260.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1716 mL	10.8582 mL	21.7165 mL	108.5823 mL
5 mM	0.4343 mL	2.1716 mL	4.3433 mL	21.7165 mL
10 mM	0.2172 mL	1.0858 mL	2.1716 mL	10.8582 mL
20 mM	0.1086 mL	0.5429 mL	1.0858 mL	5.4291 mL
50 mM	0.0434 mL	0.2172 mL	0.4343 mL	2.1716 mL
100 mM	0.0217 mL	0.1086 mL	0.2172 mL	1.0858 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc