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Tuberostemonine

Name: Tuberostemonine
Brand: TargetMol
SKU: T6S0084
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S0084Cas No. 6879-01-2

Alias Tuberstemonine

1. Tuberostemonine (Tuberstemonine) exhibits relatively higher intestinal permeabilities. 2. Tuberostemonine acts in part as an open-channel blocker at the crayfish neuromuscular junction.

Tuberostemonine

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Purity: 99.68%

Catalog No. T6S0084Alias TuberstemonineCas No. 6879-01-2

1. Tuberostemonine (Tuberstemonine) exhibits relatively higher intestinal permeabilities. 2. Tuberostemonine acts in part as an open-channel blocker at the crayfish neuromuscular junction.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$47	In Stock	In Stock
10 mg	$80	In Stock	In Stock
25 mg	$169	In Stock	In Stock
50 mg	$253	In Stock	In Stock
100 mg	$379	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.68%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Tuberostemonine AI Summary

Tuberostemonine exhibits ex vivo inhibition of leukotriene formation in calcium ionophore activated human neutrophilic granulocytes, with an IC50 value greater than 50000.0 nM as measured by ELISA. Moreover, this compound shows no toxicity in neonate larvae of Spodoptera littoralis at 100 µg/larvae, with 100% survival after treatment into the hemolymph. However, it demonstrates growth inhibition in these larvae after 5 days, with an LC50 of 500.0 ppm. Despite this, the insecticidal activity against neonate larvae after 5 days has an LC50 value greater than 500.0 ppm..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Tuberostemonine (Tuberstemonine) exhibits relatively higher intestinal permeabilities. 2. Tuberostemonine acts in part as an open-channel blocker at the crayfish neuromuscular junction.
Synonyms	Tuberstemonine

Chemical Properties

Molecular Weight	375.50
Formula	C₂₂H₃₃NO₄
Cas No.	6879-01-2
Smiles	[H][C@@]12OC(=O)[C@@H](C)[C@]1([H])[C@@]1([H])C[C@@H]([C@@H]3C[C@H](C)C(=O)O3)N3CCCC[C@]([H])([C@H]2CC)[C@]13[H]
Relative Density.	1.19 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 68.00 mg/mL (181.09 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (6.66 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6631 mL	13.3156 mL	26.6312 mL	133.1558 mL
5 mM	0.5326 mL	2.6631 mL	5.3262 mL	26.6312 mL
10 mM	0.2663 mL	1.3316 mL	2.6631 mL	13.3156 mL
20 mM	0.1332 mL	0.6658 mL	1.3316 mL	6.6578 mL
50 mM	0.0533 mL	0.2663 mL	0.5326 mL	2.6631 mL
100 mM	0.0266 mL	0.1332 mL	0.2663 mL	1.3316 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc