Powder: -20°C for 3 years | In solvent: -80°C for 1 year
G43 is a potent and selective glucosyltransferase inhibitor that inhibits GtfB and GtfC with Kd values of 3.7 μM and 46.9 nM, respectively.G43 exhibits in vitro and in vivo anti-Streptococcus mutans activity and can be used for caries studies.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
5 mg | In stock | $ 430.00 | |
10 mg | In stock | $ 636.00 | |
25 mg | In stock | $ 987.00 | |
50 mg | In stock | $ 1,360.00 | |
100 mg | In stock | $ 1,830.00 | |
500 mg | In stock | $ 3,680.00 |
Description | G43 is a potent and selective glucosyltransferase inhibitor that inhibits GtfB and GtfC with Kd values of 3.7 μM and 46.9 nM, respectively.G43 exhibits in vitro and in vivo anti-Streptococcus mutans activity and can be used for caries studies. |
In vitro |
G43 (16 h) inhibits Streptococcus mutans biofilm by 85% at a concentration of 12.5 μM.[1] G43 (25 μM; 24 h) reduces glucan production by glycosyltransferase (Gtfs) and continuously inhibits the activities of GtfB and GtfC, with an inhibition rate of 80% for both enzymes.[1] G43 (25 μM; 24 h) has no significant effect on the expression of gtfs (gtfB, gtfC and gtfD) in UA159 mutans Streptococcus mutans.[1] G43 (50 μM; 24-48 h) reduces biofilm formation by reducing the production of water-insoluble exopolysaccharides in wild-type Streptococcus mutans.[2] |
In vivo | G43 (100 µM; administered topically twice daily for 4 weeks; rat with S. mutans UA159 infected) reduces Streptococcus mutans virulence but did not lose weight over the course of the study. in vivo.[1] |
Synonyms | G 43, G-43 |
Molecular Weight | 341.34 |
Formula | C16H11N3O4S |
CAS No. | 690693-02-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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G43 690693-02-8 Metabolism Microbiology/Virology Antibacterial Transferase G 43 G-43 inhibitor inhibit