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G43

Name: G43
Brand: TargetMol
SKU: T77633
Price: 82 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77633Cas No. 690693-02-8

Alias G-43, G 43

G43 is a potent and selective glucosyltransferase inhibitor that inhibits GtfB and GtfC with Kd values of 3.7 μM and 46.9 nM, respectively.G43 exhibits in vitro and in vivo anti-Streptococcus mutans activity and can be used for caries studies.

G43

🥰Excellent

Purity: 99.21%

Catalog No. T77633Alias G-43, G 43Cas No. 690693-02-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$82	-	In Stock
5 mg	$181	-	In Stock
10 mg	$267	-	In Stock
25 mg	$413	-	In Stock
50 mg	$571	-	In Stock
100 mg	$763	-	In Stock
200 mg	$1,030	-	In Stock
1 mL x 10 mM (in DMSO)	$183	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.21%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	G43 is a potent and selective glucosyltransferase inhibitor that inhibits GtfB and GtfC with Kd values of 3.7 μM and 46.9 nM, respectively.G43 exhibits in vitro and in vivo anti-Streptococcus mutans activity and can be used for caries studies.
In vitro	G43 (16 h) inhibits Streptococcus mutans biofilm by 85% at a concentration of 12.5 μM.[1] G43 (25 μM; 24 h) reduces glucan production by glycosyltransferase (Gtfs) and continuously inhibits the activities of GtfB and GtfC, with an inhibition rate of 80% for both enzymes.[1] G43 (25 μM; 24 h) has no significant effect on the expression of gtfs (gtfB, gtfC and gtfD) in UA159 mutans Streptococcus mutans.[1] G43 (50 μM; 24-48 h) reduces biofilm formation by reducing the production of water-insoluble exopolysaccharides in wild-type Streptococcus mutans.[2]
In vivo	G43 (100 µM; administered topically twice daily for 4 weeks; rat with S. mutans UA159 infected) reduces Streptococcus mutans virulence but did not lose weight over the course of the study. in vivo.[1]
Synonyms	G-43, G 43

Chemical Properties

Molecular Weight	341.34
Formula	C₁₆H₁₁N₃O₄S
Cas No.	690693-02-8
Smiles	C(NC1=C(C(N)=O)C=CC=C1)(=O)C2=CC=3C(S2)=CC=C(N(=O)=O)C3
Relative Density.	1.534 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (131.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9296 mL	14.6482 mL	29.2963 mL	146.4815 mL
5 mM	0.5859 mL	2.9296 mL	5.8593 mL	29.2963 mL
10 mM	0.2930 mL	1.4648 mL	2.9296 mL	14.6482 mL
20 mM	0.1465 mL	0.7324 mL	1.4648 mL	7.3241 mL
50 mM	0.0586 mL	0.2930 mL	0.5859 mL	2.9296 mL
100 mM	0.0293 mL	0.1465 mL	0.2930 mL	1.4648 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc