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Piperidolate hydrochloride

Name: Piperidolate hydrochloride
Brand: TargetMol
SKU: T7555
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7555Cas No. 129-77-1

Piperidolate hydrochloride is an antimuscarinic, could restrain the abnormal activity caused by acetylcholine. inhibits intestinal cramp induced by acetylcholine (rats and dogs).

Piperidolate hydrochloride

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Purity: 99.5%

Catalog No. T7555Cas No. 129-77-1

Piperidolate hydrochloride is an antimuscarinic, could restrain the abnormal activity caused by acetylcholine. inhibits intestinal cramp induced by acetylcholine (rats and dogs).

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$48	In Stock	In Stock
50 mg	$70	In Stock	In Stock
100 mg	$105	In Stock	In Stock
200 mg	$161	-	In Stock
1 mL x 10 mM (in DMSO)	$118	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.5%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Piperidolate hydrochloride AI Summary

Piperidolate hydrochloride exhibits a diverse range of bioactivities. It functions as an IMPase inhibitor with a potency of 2238.7 nM and an AmpC Beta-Lactamase inhibitor with a potency of 4466.8 nM. The compound is involved in both activation and inhibition of Cytochrome P450 3A4 and inhibits GCN5L2 with a potency of 39810.7 nM. Additionally, it shows delayed death inhibition of the malarial parasite plastid (potency of 20786.5 nM) and induces DNA re-replication in normal breast cells (potency of 5173.5 nM) and colon adenocarcinoma cells (potency of 2511.9 nM). It inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) across various cell conditions with potencies ranging from 7176.7 nM to 18356.4 nM, and is involved in inhibiting TDP-43 and human Apurinic/apyrimidinic Endonuclease 1 (APE1). Moreover, Piperidolate hydrochloride shows activity in blocking the entry of the Ebola Virus with AC50 values from 25.12 µM to 25118.9 nM and affects insulin secretion from INS-1E cells with an IC50 of 18226.7 nM. It inhibits sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells at 10 µM, with inhibition rates of 65.65% and 96.0%, respectively. The compound exhibits antiviral activity against SARS-CoV-2, inhibiting 14.14% of virus-induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours and showing 2.167% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM. In Vero E6 cells, it demonstrates inhibitory effects on cell viability post-72-hour exposure, though the inhibition index is below 1 in comparison to control arbidol, and it exhibits -0.03% inhibition of SARS-CoV-2 induced cytotoxicity at 10 µM after 48 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Piperidolate hydrochloride is an antimuscarinic, could restrain the abnormal activity caused by acetylcholine. inhibits intestinal cramp induced by acetylcholine (rats and dogs).

Chemical Properties

Molecular Weight	359.89
Formula	C₂₁H₂₆ClNO₂
Cas No.	129-77-1
Smiles	Cl.CCN1CCCC(C1)OC(=O)C(c1ccccc1)c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32 mg/mL (88.92 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7786 mL	13.8931 mL	27.7863 mL	138.9313 mL
5 mM	0.5557 mL	2.7786 mL	5.5573 mL	27.7863 mL
10 mM	0.2779 mL	1.3893 mL	2.7786 mL	13.8931 mL
20 mM	0.1389 mL	0.6947 mL	1.3893 mL	6.9466 mL
50 mM	0.0556 mL	0.2779 mL	0.5557 mL	2.7786 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc