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B355252

Name: B355252
Brand: TargetMol
SKU: T8869
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8869Cas No. 1261576-81-1

B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth.

B355252

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Purity: 99.92%

Catalog No. T8869Cas No. 1261576-81-1

B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	-	In Stock
5 mg	$64	-	In Stock
10 mg	$92	-	In Stock
25 mg	$162	-	In Stock
1 mL x 10 mM (in DMSO)	$85	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.92%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description

B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth.

In vitro

Method: HT22 cells were pretreated for 2 hours with various concentrations of B355252 (0.625-20 μM). This was followed by the addition of 300 μM CoCl2 and incubation at 37oC for 24 hours. At the end of this time, cell viability was determined by resazurin assay as described below. Result: From 0.625 to 5 μM, B355252 increased cell viability in a dose-dependent manner, protecting against CoCl2-induced hypoxia. Above 5 μM, B355252 became toxic to the cells and, synergistically with CoCl2, decreased cell viability.

Chemical Properties

Molecular Weight	514.06
Formula	C₂₅H₂₄ClN₃O₃S₂
Cas No.	1261576-81-1
Smiles	Clc1cc(sc1Oc1cccc(c1)N1CCNCC1)S(=O)(=O)NCc1cccc2ccccc12
Relative Density.	1.370 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (48.63 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9453 mL	9.7265 mL	19.4530 mL	97.2649 mL
5 mM	0.3891 mL	1.9453 mL	3.8906 mL	19.4530 mL
10 mM	0.1945 mL	0.9726 mL	1.9453 mL	9.7265 mL
20 mM	0.0973 mL	0.4863 mL	0.9726 mL	4.8632 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc