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Vitamin K4

Name: Vitamin K4
Brand: TargetMol
SKU: T2570
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2570Cas No. 573-20-6

Alias Menadiol Diacetate, Kapilin, acetomenaphthone

Vitamin K4 (Menadiol Diacetate) is a vitamin medicine for the treatment of blood coagulation disorders that caused by the lack of VK4.

Vitamin K4

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Purity: 99.84%

Catalog No. T2570Alias Menadiol Diacetate, Kapilin, acetomenaphthoneCas No. 573-20-6

Vitamin K4 (Menadiol Diacetate) is a vitamin medicine for the treatment of blood coagulation disorders that caused by the lack of VK4.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$35	In Stock	In Stock
500 mg	$72	In Stock	In Stock
1 g	$89	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$55	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.84%

Appearance:Solid

Color:White

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COA HPLC HNMR LCMS

Product Introduction

Vitamin K4 AI Summary

Vitamin K4 exhibits a variety of bioactivities, demonstrating potent modulation of lamin A splicing with a potency of 0.8 nM. It also shows inhibitory activities against the malarial parasite plastid, induces DNA re-replication in breast and colon adenocarcinoma cells, and affects Schwann cell intronic elements and viability. Additionally, the compound has activities in assays pertaining to tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibition, acts as a GLP-1 receptor agonist, and inhibits Lassa and Marburg viruses. It has a LogP value of 3.59, indicating moderate lipophilicity, which can influence its bioavailability and distribution. Furthermore, Vitamin K4 exhibits antiviral activity against SARS-CoV-2 by inhibiting the cytotoxicity of VERO-6 cells exposed to the virus, with IC50 values greater than 20000.0 nM and 19952.62 nM in different assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Vitamin K4 (Menadiol Diacetate) is a vitamin medicine for the treatment of blood coagulation disorders that caused by the lack of VK4.
Synonyms	Menadiol Diacetate, Kapilin, acetomenaphthone

Chemical Properties

Molecular Weight	258.27
Formula	C₁₅H₁₄O₄
Cas No.	573-20-6
Smiles	O(C(C)=O)C=1C2=C(C(OC(C)=O)=C(C)C1)C=CC=C2
Relative Density.	1.2 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (106.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8719 mL	19.3596 mL	38.7192 mL	193.5958 mL
5 mM	0.7744 mL	3.8719 mL	7.7438 mL	38.7192 mL
10 mM	0.3872 mL	1.9360 mL	3.8719 mL	19.3596 mL
20 mM	0.1936 mL	0.9680 mL	1.9360 mL	9.6798 mL
50 mM	0.0774 mL	0.3872 mL	0.7744 mL	3.8719 mL
100 mM	0.0387 mL	0.1936 mL	0.3872 mL	1.9360 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc