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2-Oxobutanoic acid

Name: 2-Oxobutanoic acid
Brand: TargetMol
SKU: T5060
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5060Cas No. 600-18-0

Alias Propionylformic acid, alpha-Ketobutyric Acid, 2-Oxobutyric acid

2-Oxobutanoic acid (alpha-Ketobutyric Acid) is a product of the lysis of cystathionine. It is also one of the degradation products of threonine. It can be converted into propionyl-CoA, and thus enter the citric acid cycle.

2-Oxobutanoic acid

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Purity: 99.47%

Catalog No. T5060Alias Propionylformic acid, alpha-Ketobutyric Acid, 2-Oxobutyric acidCas No. 600-18-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.47%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	2-Oxobutanoic acid (alpha-Ketobutyric Acid) is a product of the lysis of cystathionine. It is also one of the degradation products of threonine. It can be converted into propionyl-CoA, and thus enter the citric acid cycle.
In vivo	Brequinar sodium-treated (10-20 mg/kg/day) mice has a 31% reduction in percentage of packed cell volume compared with untreated BALB/c mice. Brequinar sodium reduces UTP and CTP levels in bone marrow cells by 30 and 25%, respectively.
Synonyms	Propionylformic acid, alpha-Ketobutyric Acid, 2-Oxobutyric acid

Chemical Properties

Molecular Weight	102.09
Formula	C₄H₆O₃
Cas No.	600-18-0
Smiles	CCC(=O)C(O)=O
Relative Density.	1.182 g/cm3

Storage & Solubility Information

Storage

store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (2448.82 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (19.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	9.7953 mL	48.9764 mL	97.9528 mL	489.7639 mL
5 mM	1.9591 mL	9.7953 mL	19.5906 mL	97.9528 mL
10 mM	0.9795 mL	4.8976 mL	9.7953 mL	48.9764 mL
20 mM	0.4898 mL	2.4488 mL	4.8976 mL	24.4882 mL
50 mM	0.1959 mL	0.9795 mL	1.9591 mL	9.7953 mL
100 mM	0.0980 mL	0.4898 mL	0.9795 mL	4.8976 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc