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2-Oxobutanoic acid

Name: 2-Oxobutanoic acid
Brand: TargetMol
SKU: T5060
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5060Cas No. 600-18-0

Alias Propionylformic acid, alpha-Ketobutyric Acid, 2-Oxobutyric acid

2-Oxobutanoic acid (alpha-Ketobutyric Acid) is a product of the lysis of cystathionine. It is also one of the degradation products of threonine. It can be converted into propionyl-CoA, and thus enter the citric acid cycle.

2-Oxobutanoic acid

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Purity: 99.47%

Catalog No. T5060Alias Propionylformic acid, alpha-Ketobutyric Acid, 2-Oxobutyric acidCas No. 600-18-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.47%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	2-Oxobutanoic acid (alpha-Ketobutyric Acid) is a product of the lysis of cystathionine. It is also one of the degradation products of threonine. It can be converted into propionyl-CoA, and thus enter the citric acid cycle.
In vivo	Brequinar sodium-treated (10-20 mg/kg/day) mice has a 31% reduction in percentage of packed cell volume compared with untreated BALB/c mice. Brequinar sodium reduces UTP and CTP levels in bone marrow cells by 30 and 25%, respectively.
Synonyms	Propionylformic acid, alpha-Ketobutyric Acid, 2-Oxobutyric acid

Chemical Properties

Molecular Weight	102.09
Formula	C₄H₆O₃
Cas No.	600-18-0
Smiles	CCC(=O)C(O)=O
Relative Density.	1.182 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (440.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (19.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	9.7953 mL	48.9764 mL	97.9528 mL	489.7639 mL
5 mM	1.9591 mL	9.7953 mL	19.5906 mL	97.9528 mL
10 mM	0.9795 mL	4.8976 mL	9.7953 mL	48.9764 mL
20 mM	0.4898 mL	2.4488 mL	4.8976 mL	24.4882 mL
50 mM	0.1959 mL	0.9795 mL	1.9591 mL	9.7953 mL
100 mM	0.0980 mL	0.4898 mL	0.9795 mL	4.8976 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc