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3-Methyl-2-oxobutanoic acid

Name: 3-Methyl-2-oxobutanoic acid
Brand: TargetMol
SKU: T5232
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5232Cas No. 759-05-7

Alias alpha-Ketoisovaleric acid, 2-Oxoisovaleric acid

3-Methyl-2-oxobutanoic acid (2-Oxoisovaleric acid) is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids. 3-Methyl-2-oxobutanoic acid is a neurotoxin, an acidogen, and a metabotoxin. A neurotoxin causes damage to nerve cells and nerve tissues. 3-Methyl-2-oxobutanoic acid is a keto-acid, which is a subclass of organic acids. Abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis.

3-Methyl-2-oxobutanoic acid

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Purity: 95%

Catalog No. T5232Alias alpha-Ketoisovaleric acid, 2-Oxoisovaleric acidCas No. 759-05-7

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$31	In Stock	In Stock
100 mg	$56	In Stock	In Stock
500 mg	$133	-	In Stock
1 g	$195	-	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:95%

Appearance:Liquid

Color:Transparent

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description

Synonyms

alpha-Ketoisovaleric acid, 2-Oxoisovaleric acid

Chemical Properties

Molecular Weight	116.12
Formula	C₅H₈O₃
Cas No.	759-05-7
Smiles	CC(C)C(=O)C(O)=O
Relative Density.	1.125 g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (861.18 mM), Sonication and heating are recommended.

DMSO: 30 mg/mL (258.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (17.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	8.6118 mL	43.0589 mL	86.1178 mL	430.5890 mL
5 mM	1.7224 mL	8.6118 mL	17.2236 mL	86.1178 mL
10 mM	0.8612 mL	4.3059 mL	8.6118 mL	43.0589 mL
20 mM	0.4306 mL	2.1529 mL	4.3059 mL	21.5295 mL
50 mM	0.1722 mL	0.8612 mL	1.7224 mL	8.6118 mL
100 mM	0.0861 mL	0.4306 mL	0.8612 mL	4.3059 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc