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Glycocholic acid hydrate

Name: Glycocholic acid hydrate
Brand: TargetMol
SKU: T5072
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5072Cas No. 1192657-83-2

Glycocholic Acid is the product of conjugation of cholic acid with glycine. It is the chief ingredient of the bile of herbivorous animals.

Glycocholic acid hydrate

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Purity: 99.91%

Catalog No. T5072Cas No. 1192657-83-2

Glycocholic Acid is the product of conjugation of cholic acid with glycine. It is the chief ingredient of the bile of herbivorous animals.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$42	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Glycocholic acid hydrate AI Summary

Glycocholic acid hydrate exhibits a range of bioactivities with various potencies. It inhibits MLL CXXC domain-DNA interaction (50118.7 nM), ELG1-dependent DNA repair in HEK293T cells (460.9 nM), and RanGTP-induced Rango-Importin beta complex dissociation (206.0 nM). Additionally, it inhibits Human Flap endonuclease 1 (FEN1) with a potency of 89125.1 nM and induces DNA re-replication in SW480 colon adenocarcinoma cells at 1258.9 nM. It also shows antagonistic activity against the gsp mutation responsible for Fibrous Dysplasia/McCune-Albright Syndrome, with an inhibitory potency of 28183.8 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Glycocholic Acid is the product of conjugation of cholic acid with glycine. It is the chief ingredient of the bile of herbivorous animals.

Chemical Properties

Molecular Weight	483.63
Formula	C₂₆H₄₅NO₇
Cas No.	1192657-83-2
Smiles	O.C[C@H](CCC(=O)NCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (113.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0677 mL	10.3385 mL	20.6770 mL	103.3848 mL
5 mM	0.4135 mL	2.0677 mL	4.1354 mL	20.6770 mL
10 mM	0.2068 mL	1.0338 mL	2.0677 mL	10.3385 mL
20 mM	0.1034 mL	0.5169 mL	1.0338 mL	5.1692 mL
50 mM	0.0414 mL	0.2068 mL	0.4135 mL	2.0677 mL
100 mM	0.0207 mL	0.1034 mL	0.2068 mL	1.0338 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc