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Antibacterialagent 205 (Compound 10d) is an indole propene acyl-derived oxazaanthracene compound with a broad antibacterial spectrum, exhibiting a MIC of 0.25 to 0.5 μg/mL. It reduces extracellular polysaccharides and eliminates biofilms, thereby mitigating resistance. Antibacterialagent 205 exerts antibacterial effects by disrupting membrane integrity, accumulating reactive oxygen species (ROS), and inhibiting DNA replication.
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| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
| Description | Antibacterialagent 205 (Compound 10d) is an indole propene acyl-derived oxazaanthracene compound with a broad antibacterial spectrum, exhibiting a MIC of 0.25 to 0.5 μg/mL. It reduces extracellular polysaccharides and eliminates biofilms, thereby mitigating resistance. Antibacterialagent 205 exerts antibacterial effects by disrupting membrane integrity, accumulating reactive oxygen species (ROS), and inhibiting DNA replication. |
| In vitro | Antibacterial agent 205 exhibits antibacterial activity against Enterococcus, Staphylococcus, Escherichia, Acinetobacter, and Pseudomonas strains, with a minimum inhibitory concentration (MIC) of 0.25-0.5 μg/mL. It shows low hemolytic activity at concentrations of 0-256 μg/mL and exhibits low cytotoxicity to human blood, liver cells (LO2), and HUVECs, maintaining good compatibility with red blood cells. |
| Formula | C32H30FN5O6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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