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Anti-CIITA Polyclonal Antibody
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Catalog No. TMAB-00433
Alias Nucleotide binding oligomerization domain leucine rich repeat and acid domain containing, NLRA, NLR family acid domain containing, MHC2TA, MHC class II transactivator type III, MHC class II transactivator, class II transactivator, class II major histocompatibility complex transactivator, CIITA IV, CIITA, C2TA
Anti-CIITA Polyclonal Antibody is a Rabbit antibody targeting CIITA. Anti-CIITA Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB.
Anti-CIITA Polyclonal Antibody
Anti-CIITA Polyclonal Antibody
😃Good
Catalog No. TMAB-00433Alias Nucleotide binding oligomerization domain leucine rich repeat and acid domain containing, NLRA, NLR family acid domain containing, MHC2TA, MHC class II transactivator type III, MHC class II transactivator, class II transactivator, class II major histocompatibility complex transactivator, CIITA IV, CIITA, C2TA
Anti-CIITA Polyclonal Antibody is a Rabbit antibody targeting CIITA. Anti-CIITA Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-CIITA Polyclonal Antibody is a Rabbit antibody targeting CIITA. Anti-CIITA Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB. |
| Synonyms | Nucleotide binding oligomerization domain leucine rich repeat and acid domain containing, NLRA, NLR family acid domain containing, MHC2TA, MHC class II transactivator type III, MHC class II transactivator, class II transactivator, class II major histocompatibility complex transactivator, CIITA IV, CIITA, C2TA |
| Ig Type | IgG |
| Reactivity | (predicted:Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated synthetic peptide: human CIITA |
| Antigen Species | Human |
| Gene Name | CIITA |
| Gene ID | |
| Protein Name | MHC class II transactivator |
| Uniprot ID | |
| Biology Area | Other factors,Class II |
| Function | Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. |
| Molecular Weight | Theoretical: 123 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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