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Anti-Phospho-GSK3B (Ser 9) Antibody (9V640)

(Synonyms: p-GSK3B (Ser 9), p-GSK3B (S 9), GSK3B (p-Ser 9), GSK3B (p-S 9)) Copy Product Info
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Synonyms: p-GSK3B (Ser 9), p-GSK3B (S 9), GSK3B (p-Ser 9), GSK3B (p-S 9)

Catalog No. TMAC-03220 Copy Product Info
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Anti-Phospho-GSK3B (Ser 9) Antibody (9V640) is a Rabbit antibody targeting Phospho-GSK3B (Ser 9). Anti-Phospho-GSK3B (Ser 9) Antibody (9V640) can be used in ICC/IF,IHC,WB.
Anti-Phospho-GSK3B
(Ser 9) Antibody
(9V640)
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2977-10 days7-10 days
100 μL$4987-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-Phospho-GSK3B (Ser 9) Antibody (9V640) is a Rabbit antibody targeting Phospho-GSK3B (Ser 9). Anti-Phospho-GSK3B (Ser 9) Antibody (9V640) can be used in ICC/IF,IHC,WB.
Synonymsp-GSK3B (Ser 9), p-GSK3B (S 9), GSK3B (p-Ser 9), GSK3B (p-S 9)
Ig Type
IgG
Clone
9V640
Reactivity
Human
Application
Recommended Dose
WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundGlycogen synthase kinase-3α (GSK-3α) and GSK-3β are highly similar isoforms of serine/ threonine kinases that regulate metabolic enzymes and transcription factors, which are responsible for coordinating processes such as glycogen synthesis and cell adhesion. GSK-3β activity is also required for nuclear activity of Rel dimers, which mediate an apoptotic response to TNFα in mice. GSK-3 catalytic kinase activity is controlled through differential phosphorylation of serine/threonine residues, which have an inhibitory effect, and tyrosine residues, which have an activating effect. Growth factor stimulation of mammalian cells expressing GSK-3α and GSK-3β induces phosphorylation of Ser 21 and Ser 9, respectively, through a phosphatidylinositol 3-kinase (PI 3-K)-protein kinase B (PKB)-dependent pathway, thereby enhancing proliferative signals. Additionally, GSK-3 physically associates with cAMP-dependent protein kinase A (PKA), which phosphorylates Ser 21 of GSK-3α or Ser 9 of GSK-3β and inactivates both forms. GSK-3α/β is positively regulated by phosphorylation on Tyr 279 and Tyr 216, respectively. Activated GSK-3α/β participates in energy metabolism, neuronal cell development, and body pattern formation. Tyrosine dephosphorylation of GSK-3 is involved in its extracellular signal-dependent inactivation.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
A synthesized phosphopeptide: human GSK3 beta around the phosphorylation site of Ser9
Antigen Species
Human
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 47 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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