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Kresoxim-Methyl

Name: Kresoxim-Methyl
Brand: TargetMol
SKU: T7922
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7922Cas No. 143390-89-0

Kresoxim-methyl is a strobilurin fungicide,inhibits conidial germination of V. inaequalis isolates from apple orchards .

Kresoxim-Methyl

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Purity: 99.24%

Catalog No. T7922Cas No. 143390-89-0

Kresoxim-methyl is a strobilurin fungicide,inhibits conidial germination of V. inaequalis isolates from apple orchards .

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$50	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.24%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Kresoxim-Methyl AI Summary

Kresoxim-Methyl exhibits a broad spectrum of bioactivities, including potent antifungal, antiviral, and cytotoxic properties. It demonstrates strong antifungal activity against multiple fungal species such as Rhizoctonia solani, Botrytis cinerea, Gibberella zeae, Physalospora piricola, and Bipolaris maydis, with high inhibition percentages ranging from 66.1% to 98.5% at a concentration of 50 µg/mL. Specifically, it is effective against Pseudoperonospora cubensis and Podosphaera fuliginea in cucumber plants, achieving up to 100% disease control. Additionally, Kresoxim-Methyl inhibits germ-tube development of Pyricularia grisea with an EC50 value of 0.003 µg/mL and shows fungicidal activity with varying EC50 and EC90 values against different fungal pathogens. In antiviral assays, Kresoxim-Methyl has shown inhibitory effects on the SARS-CoV-2 3CL-Pro protease, with an inhibition percentage of 26.31% at 20 µM, and has demonstrated antiviral activity against SARS-CoV-2-induced cytotoxicity in VERO-6 cells at 10 µM concentration. Furthermore, Kresoxim-Methyl acts as an agonist and antagonist for various receptor signaling pathways and demonstrates significant cytotoxicity against human HepG2 cells with an IC50 value of 12500.0 nM. It also inhibits the Sus scrofa heart cytochrome bc1 complex, suggesting additional bioactivity as a cytochrome bc1 complex inhibitor. With its diverse bioactivities, Kresoxim-Methyl shows promising potential as both a fungicidal and antiviral agent, while also exhibiting cytotoxic properties useful for selective applications in research and therapeutic developments..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Kresoxim-methyl is a strobilurin fungicide,inhibits conidial germination of V. inaequalis isolates from apple orchards .

Chemical Properties

Molecular Weight	313.35
Formula	C₁₈H₁₉NO₄
Cas No.	143390-89-0
Smiles	CO\N=C(\C(=O)OC)c1ccccc1COc1ccccc1C
Relative Density.	1.1 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (95.74 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.38 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1913 mL	15.9566 mL	31.9132 mL	159.5660 mL
5 mM	0.6383 mL	3.1913 mL	6.3826 mL	31.9132 mL
10 mM	0.3191 mL	1.5957 mL	3.1913 mL	15.9566 mL
20 mM	0.1596 mL	0.7978 mL	1.5957 mL	7.9783 mL
50 mM	0.0638 mL	0.3191 mL	0.6383 mL	3.1913 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc