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Etofylline

Name: Etofylline
Brand: TargetMol
SKU: T0829
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0829Cas No. 519-37-9

Alias Oxyphylline, Cordalin, Aethophyllinum, 7-Theophyllineethanol, 7-(β-Hydroxyethyl)theophylline

Etofylline (Oxyphylline) is used for difficulty in breathing, asthma, breathing difficulty and other conditions.

Etofylline

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Purity: 99.36%

Catalog No. T0829Alias Oxyphylline, Cordalin, Aethophyllinum, 7-Theophyllineethanol, 7-(β-Hydroxyethyl)theophyllineCas No. 519-37-9

Etofylline (Oxyphylline) is used for difficulty in breathing, asthma, breathing difficulty and other conditions.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$54	-	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.36%

Appearance:Solid

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Etofylline AI Summary

Etofylline exhibits diverse bioactivities targeting various biological pathways and receptors. It demonstrates moderate inhibition of adenosine A1 receptors with a Ki value of 105,000 nM and antagonizes cyclic AMP accumulation with a Ki value of 135,000 nM in guinea pig cerebral cortical slices. It displays higher affinity for adenosine A2 receptors with a selectivity ratio of 0.8 and significant binding to the human Adenosine A2B receptor with a Ki value of 17,300 nM. The compound induces calcium release in PC12 cells at a concentration of 2 mM, achieving 43% of the response produced by 1 mM caffeine. Additionally, it shows bronchodilatory activity in guinea pig trachea with 40% activity at 30 μg/ml. Etofylline also exhibits inhibition of OATP1B1 and OATP1B3 transporters, with 64.41% and 86.25% inhibition of sodium fluorescein uptake in respective transfected CHO cells at 10 μM. While it shows low antiviral activity against SARS-CoV-2 in various assays, its potential as an OATP1B1 and OATP1B3 inhibitor and an HDAC6 enzyme inhibitor with 40.16% inhibition in enzymatic assays suggests diverse therapeutic applications. The compound also exhibits bioactivity across other targets including inducing DNA re-replication in normal breast cells, inhibiting chronic active B-cell receptor signaling, and blocking the entry of the Ebola virus..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Etofylline (Oxyphylline) is used for difficulty in breathing, asthma, breathing difficulty and other conditions.
Synonyms	Oxyphylline, Cordalin, Aethophyllinum, 7-Theophyllineethanol, 7-(β-Hydroxyethyl)theophylline

Chemical Properties

Molecular Weight	224.22
Formula	C₉H₁₂N₄O₃
Cas No.	519-37-9
Smiles	CN1C2=C(N(CCO)C=N2)C(=O)N(C)C1=O
Relative Density.	1.51g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (89.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4599 mL	22.2995 mL	44.5991 mL	222.9953 mL
5 mM	0.8920 mL	4.4599 mL	8.9198 mL	44.5991 mL
10 mM	0.4460 mL	2.2300 mL	4.4599 mL	22.2995 mL
20 mM	0.2230 mL	1.1150 mL	2.2300 mL	11.1498 mL
50 mM	0.0892 mL	0.4460 mL	0.8920 mL	4.4599 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc