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Rhapontin

Name: Rhapontin
Brand: TargetMol
SKU: T5S0384
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5S0384Cas No. 155-58-8

Alias Rhapontigenin glucoside, Rhaponticin, Rhaponiticin, Ponticin

1. Rhapontin (Ponticin) can alleviate liver steatosis and improve blood glucose and lipid profiles in KK/Ay diabetic mice, indicates that rhaponticin has a noticeable antidiabetic effect and could be potentially used as a new agent to treat type 2 diabetes mellitus and its complications.

Rhapontin

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Purity: 99.91%

Catalog No. T5S0384Alias Rhapontigenin glucoside, Rhaponticin, Rhaponiticin, PonticinCas No. 155-58-8

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$35	In Stock	In Stock
25 mg	$73	In Stock	In Stock
50 mg	$106	In Stock	In Stock
100 mg	$156	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Rhapontin AI Summary

Rhapontin is a multifaceted bioactive molecule displaying various inhibitory activities and bioactivities across different biological systems. It shows inhibitory activity against nitric oxide production in LPS-activated mouse peritoneal macrophages, achieving 25.0% inhibition at a concentration of 100 µM and an IC50 value greater than 100,000 nM. Additionally, it inhibits yeast alpha-glucosidase with an IC50 of 600.0 µg/mL. In enzyme inhibition studies, Rhapontin exhibits marginal inhibitory effects on both electric eel AChE (-3.62%) and horse BChE (-4.38%) at a concentration of 2 mg/mL, as determined by Ellman's method. In cancer assays, the compound demonstrates significant antitumor activity against folate receptor (FR)-positive human KB cells with an IC50 value of 34.0 nM, assessed using the MTT proliferation assay, and has a half-life of 3.5 hours in human serum at 37°C. It also inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells at an equimolar concentration of 10 µM, showing inhibitions of 166.21% and 100.59%, respectively. Rhapontin moderately inhibits recombinant human angiotensin-converting enzyme (ACE) at a concentration of 100 µM, with an inhibition level of 18.25%. It exhibits estrogenic activity within HepG2 cells co-expressing ERalpha/ERbeta, with a transcriptional activation fold change of 1.2 at both 1 µM and 10 µM concentrations. Moreover, the compound has a measured log P value of 0.74, indicating moderate hydrophobicity, which may suggest an ability to cross cell membranes or interact with lipophilic targets. Despite its broad activities, Rhapontin shows limited antiproliferative capacity against human HepG2 and HCCLM3 cells, with IC50 values higher than 100,000 nM, and inhibits pyruvate carboxylase in human HCCLM3 cell lysate with an IC50 higher than 50,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Rhapontin (Ponticin) can alleviate liver steatosis and improve blood glucose and lipid profiles in KK/Ay diabetic mice, indicates that rhaponticin has a noticeable antidiabetic effect and could be potentially used as a new agent to treat type 2 diabetes mellitus and its complications.
Synonyms	Rhapontigenin glucoside, Rhaponticin, Rhaponiticin, Ponticin

Chemical Properties

Molecular Weight	420.41
Formula	C₂₁H₂₄O₉
Cas No.	155-58-8
Smiles	COc1ccc(\C=C\c2cc(O)cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c2)cc1O
Relative Density.	1.2828 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: Soluble

DMSO: 250 mg/mL (594.66 mM), Sonication is recommended.

Pyridine, Methanol, etc.: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3786 mL	11.8932 mL	23.7863 mL	118.9315 mL
5 mM	0.4757 mL	2.3786 mL	4.7573 mL	23.7863 mL
10 mM	0.2379 mL	1.1893 mL	2.3786 mL	11.8932 mL
20 mM	0.1189 mL	0.5947 mL	1.1893 mL	5.9466 mL
50 mM	0.0476 mL	0.2379 mL	0.4757 mL	2.3786 mL
100 mM	0.0238 mL	0.1189 mL	0.2379 mL	1.1893 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc