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Lindleyin

Name: Lindleyin
Brand: TargetMol
SKU: TN1052
Price: 480 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1052Cas No. 59282-56-3

Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.

Lindleyin

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Purity: 99.74%

Catalog No. TN1052Cas No. 59282-56-3

Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$132	In Stock	In Stock
5 mg	$323	In Stock	-
10 mg	$480	In Stock	-
25 mg	Inquiry	In Stock	-
50 mg	Inquiry	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$330	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.74%

Resource Download

COA HPLC

Product Introduction

Bioactivity

Description

Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.

In vitro

One herbal extract, Rhei rhizoma (rhubarb), acts as an agonist to both ERalpha and ERbeta. The phytochemical Lindleyin, a major component of rhubarb, might contribute to this estrogenic activity through ERalpha and ERbeta. 4-Hydroxytamoxifen, an ER antagonist, completely reversed the estrogenic activity of Lindleyin. Lindleyin binds to ERalpha in vitro, as demonstrated using a fluorescent polarization assay. The in vivo effect of rhubarb extract was studied using a vitellogenin assay system in the freshwater fish, Japanese medaka (Oryzias latipes). There were marked increases in serum vitellogenin levels in male medaka exposed to rhubarb extract[1]

Chemical Properties

Molecular Weight	478.45
Formula	C₂₃H₂₆O₁₁
Cas No.	59282-56-3
Smiles	CC(=O)CCc1ccc(O[C@@H]2O[C@H](COC(=O)c3cc(O)c(O)c(O)c3)[C@@H](O)[C@H](O)[C@H]2O)cc1
Relative Density.	1.497g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (209.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0901 mL	10.4504 mL	20.9008 mL	104.5041 mL
5 mM	0.4180 mL	2.0901 mL	4.1802 mL	20.9008 mL
10 mM	0.2090 mL	1.0450 mL	2.0901 mL	10.4504 mL
20 mM	0.1045 mL	0.5225 mL	1.0450 mL	5.2252 mL
50 mM	0.0418 mL	0.2090 mL	0.4180 mL	2.0901 mL
100 mM	0.0209 mL	0.1045 mL	0.2090 mL	1.0450 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc