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Ziftomenib

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Catalog No. T39585Cas No. 2134675-36-6
Alias KO-539

Ziftomenib (KO-539) is an inhibitor of menin-MLL interaction with antitumor activity, suitable for leukemia research.

Ziftomenib

Ziftomenib

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Purity: 99.99%
Catalog No. T39585Alias KO-539Cas No. 2134675-36-6
Ziftomenib (KO-539) is an inhibitor of menin-MLL interaction with antitumor activity, suitable for leukemia research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$115In StockIn Stock
5 mg$286In StockIn Stock
10 mg$392In StockIn Stock
25 mg$643In StockIn Stock
50 mg$987In StockIn Stock
100 mg$1,460In StockIn Stock
200 mg$1,970-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.99%
Appearance:Solid
Color:White to Yellow
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Product Introduction

Bioactivity
Description
Ziftomenib (KO-539) is an inhibitor of menin-MLL interaction with antitumor activity, suitable for leukemia research.
In vitro
Zifomenib acts highly selective in MLL-r and NPM1mut acute myeloid leukemia and synergizes with a variety of targeted drugs in vitro[1].
SynonymsKO-539
Chemical Properties
Molecular Weight717.871
FormulaC33H42F3N9O2S2
Cas No.2134675-36-6
SmilesCNc1nc(NC2CCN(Cc3ccc4n(C[C@H](C)N5CCN(CC5)S(C)(=O)=O)c(cc4c3C)C#N)CC2)c2cc(CC(F)(F)F)sc2n1
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (111.44 mM), Sonification is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.6 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3930 mL6.9650 mL13.9301 mL69.6504 mL
5 mM0.2786 mL1.3930 mL2.7860 mL13.9301 mL
10 mM0.1393 mL0.6965 mL1.3930 mL6.9650 mL
20 mM0.0697 mL0.3483 mL0.6965 mL3.4825 mL
50 mM0.0279 mL0.1393 mL0.2786 mL1.3930 mL
100 mM0.0139 mL0.0697 mL0.1393 mL0.6965 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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