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Quinestrol
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Catalog No. T0040Cas No. 152-43-2
Alias W-3566, Ethinylestradiol 3-cyclopentyl ether, EE2CPE
Quinestrol (Ethinylestradiol 3-cyclopentyl ether) is a synthetic estrogen, applied in hormone replacement therapy, and occasionally to use in cancer and prostate cancer treatment.
Quinestrol
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Purity: 99.72%
Catalog No. T0040Alias W-3566, Ethinylestradiol 3-cyclopentyl ether, EE2CPECas No. 152-43-2
Quinestrol (Ethinylestradiol 3-cyclopentyl ether) is a synthetic estrogen, applied in hormone replacement therapy, and occasionally to use in cancer and prostate cancer treatment.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $41 | In Stock | In Stock | |
| 100 mg | $59 | In Stock | In Stock | |
| 200 mg | $72 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.72%
Color:White
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Product Introduction
Quinestrol AI Summary
Quinestrol demonstrates a variety of bioactivities, exhibiting potency as a modulator of Lamin A splicing at 112.2 nM and cytotoxicity against pathogens like Streptococcus, SK(-)GAS Group A Streptococcus, and Trypanosoma cruzi with EC50 values from 1941.0 nM to 4431.0 nM. It inhibits targets such as Tau fibril formation, Mycobacterium tuberculosis, influenza NS1 protein function, human alpha-glucosidase, BAZ2B, USP1/UAF1, and FEN1 with potencies between 35480.0 nM and 79432.8 nM. Additionally, it induces DNA re-replication, promotes mRNA translation, and regulates enzymatic functions.
Moreover, Quinestrol shows significant estrogenic activities:
- In immature rats, it exhibits an estrogenic activity ratio of 1.66 relative to ethynylestradiol.
- Induces vaginal cornification in ovariectomized mature rats at 0.005 to 0.010 mg/kg orally, with 40.0% activity relative to control.
- Displaces 17beta-[3H]estradiol from rabbit uterine estrogen receptor with an IC50 of 6000.0 nM and a relative ratio to ethynylestradiol of 0.00004.
In spayed Wistar rats, Quinestrol shows uterotrophic activity with uterus weights of 39.0 mg after 1 week and 29.0 mg after 2 weeks at a 0.1 µmol oral dosage.
Its antiviral properties include:
- Inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM with 4.68% inhibition after 48 hours.
- Moderate efficacy against SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells, with a hit score of 0.3887 after 96 hours.
- Inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM with an inhibition percentage of -0.2126%.
- Inhibition of cytotoxicity in VERO-6 cells with 0.14% inhibition at 10 µM after 48 hours of exposure.
The compound also displays high binding affinity towards multiple receptors, including human NPY1R, CNR1, AVPR1A, AVPR2, BDKRB2, GHSR, NR3C1, AGTR1, CCKAR, MC3R, MC4R, and others, with AC50 values exceeding 10000.0 nM. Agonist activity at human PGR is observed with an AC50 of 221.0 nM, along with antagonist activity at receptors like CHRM2, HTR1A, ADRA2A, HTR2A, and HTR2B with AC50 values above 10000.0 nM. It also inhibits enzymes PTGS2, PDE4D, PDE3A, and MAOA in cell-free assays with AC50 values surpassing 10000.0 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Quinestrol (Ethinylestradiol 3-cyclopentyl ether) is a synthetic estrogen, applied in hormone replacement therapy, and occasionally to use in cancer and prostate cancer treatment. |
| Synonyms | W-3566, Ethinylestradiol 3-cyclopentyl ether, EE2CPE |
| Molecular Weight | 364.52 |
| Formula | C25H32O2 |
| Cas No. | 152-43-2 |
| Smiles | [H][C@@]12CC[C@@](O)(C#C)[C@@]1(C)CC[C@]1([H])c3ccc(OC4CCCC4)cc3CC[C@@]21[H] |
| Relative Density. | 1.15 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: < 1 mg/mL (insoluble or slightly soluble), Sonication is recommended.  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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