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Ganaplacide hydrochloride
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Catalog No. T62677Cas No. 2751586-94-2
Ganaplacide hydrochloride (KAF156 HCl) is an orally administered imidazopyrimidine antimalarial agent that inhibits Plasmodium PI4K activity. It exhibits activity against Plasmodium falciparum, Plasmodium vivax, and artemisinin-resistant parasites, including artemisinin-resistant strains, and exerts effects during both the blood and liver stages.
Ganaplacide hydrochloride
🥰Excellent
Catalog No. T62677Cas No. 2751586-94-2
Ganaplacide hydrochloride (KAF156 HCl) is an orally administered imidazopyrimidine antimalarial agent that inhibits Plasmodium PI4K activity. It exhibits activity against Plasmodium falciparum, Plasmodium vivax, and artemisinin-resistant parasites, including artemisinin-resistant strains, and exerts effects during both the blood and liver stages.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $189 | In Stock | |
| 5 mg | $479 | In Stock | |
| 10 mg | $728 | In Stock | |
| 25 mg | $1,380 | In Stock | |
| 50 mg | $2,090 | In Stock | |
| 100 mg | $2,830 | In Stock |
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Chemical Properties
| Description | Ganaplacide hydrochloride (KAF156 HCl) is an orally administered imidazopyrimidine antimalarial agent that inhibits Plasmodium PI4K activity. It exhibits activity against Plasmodium falciparum, Plasmodium vivax, and artemisinin-resistant parasites, including artemisinin-resistant strains, and exerts effects during both the blood and liver stages. |
| In vitro | Methods: The SYBR Green proliferation assay was employed to evaluate the inhibitory effect of Ganaplacide hydrochloride on laboratory-adapted Plasmodium falciparum strains and clinical dissociation strains. Results: The IC50 values of Ganaplacide hydrochloride against multiple drug-resistant strains ranged from 6 to 17.4 nM. [1] |
| In vivo | Method: Ganaplacide hydrochloride (1-15 mg/kg) was administered orally for causal prophylaxis in rodent malaria model mice, and the prophylactic activity of KAF156 was monitored through blood smear analysis. Result: A single oral dose of 10 mg/kg Ganaplacide hydrochloride administered 2 hours before infection completely protected the mice. [1] |
| Molecular Weight | 447.91 |
| Formula | C22H24ClF2N5O |
| Cas No. | 2751586-94-2 |
| Smiles | Cl.O=C(N1CCN2C(=NC(C3=CC=C(F)C=C3)=C2NC4=CC=C(F)C=C4)C1(C)C)CN |
| Relative Density. | no data available |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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