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Licochalcone C

Name: Licochalcone C
Brand: TargetMol
SKU: T7028
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7028Cas No. 144506-14-9

Alias LICOCHALCONEC

Licochalcone C (LICOCHALCONEC) has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, anti-inflammatory, and anti-apoptotic activities. Licochalcone C exhibit inhibitory activity with cytotoxicity in a rat basophilic leukaemia cell line, RBL-2H3. Licochalcone C induces apoptosis via B-cell lymphoma 2 family proteins in T24 cells, it may be a potential adjuvant therapeutic agent for bladder cancer.

Licochalcone C

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Purity: 99.93%

Catalog No. T7028Alias LICOCHALCONECCas No. 144506-14-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$118	In Stock	In Stock
5 mg	$297	In Stock	In Stock
10 mg	$438	In Stock	In Stock
25 mg	$696	In Stock	In Stock
50 mg	$982	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$293	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.93%

Color:Yellow

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COA

Product Introduction

Licochalcone C AI Summary

Licochalcone C exhibits a range of bioactivities, including antiparasitic, immunomodulatory, anti-inflammatory, and anticancer properties. It effectively inhibits the growth of Leishmania major in vitro, with dose-dependent inhibition of [3H]-thymidine uptake ranging from 3.9% to 93.8%. The compound also suppresses PHA-induced proliferation of human peripheral lymphocytes (5.5% to 73.2% inhibition). Additionally, it demonstrates inhibitory activity against recombinant human PTP1B (IC50 = 30900.0 nM and IC50 = 57000.0 nM in different assays) and inhibits degranulation in RBL2H3 cells (IC50 = 24000.0 nM). In cancer research, Licochalcone C inhibits growth in human MCF7, SW480, and HepG2 cells with inhibition rates of 26.0%, 25.0%, and 22.0% at 10 uM after 24 hours, respectively. It also reduces LPS-induced NO production in mouse RAW264.7 cells (1.0% inhibition) and suppresses NF-kappaB transcription in human SW480 cells (9.0% inhibition). Furthermore, the compound moderately inhibits mushroom tyrosinase and stimulates the Nrf2 pathway in human HepG2 cells, enhancing ARE-driven luciferase expression by 1.42-fold at 10 uM, suggesting potential antioxidant and cytoprotective properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Licochalcone C (LICOCHALCONEC) has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, anti-inflammatory, and anti-apoptotic activities. Licochalcone C exhibit inhibitory activity with cytotoxicity in a rat basophilic leukaemia cell line, RBL-2H3. Licochalcone C induces apoptosis via B-cell lymphoma 2 family proteins in T24 cells, it may be a potential adjuvant therapeutic agent for bladder cancer.
Targets&IC50	α-glucosidase:<100 nM, PTP1B:92.43 μM
Synonyms	LICOCHALCONEC

Chemical Properties

Molecular Weight	338.4
Formula	C₂₁H₂₂O₄
Cas No.	144506-14-9
Smiles	COc1c(\C=C\C(=O)c2ccc(O)cc2)ccc(O)c1CC=C(C)C
Relative Density.	1.181 g/cm3 at 20℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: Soluble

DMSO: 60 mg/mL (177.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9551 mL	14.7754 mL	29.5508 mL	147.7541 mL
5 mM	0.5910 mL	2.9551 mL	5.9102 mL	29.5508 mL
10 mM	0.2955 mL	1.4775 mL	2.9551 mL	14.7754 mL
20 mM	0.1478 mL	0.7388 mL	1.4775 mL	7.3877 mL
50 mM	0.0591 mL	0.2955 mL	0.5910 mL	2.9551 mL
100 mM	0.0296 mL	0.1478 mL	0.2955 mL	1.4775 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc