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IMD-0560
🥰Excellent
Catalog No. T15564Cas No. 439144-66-8
IMD-0560 is a novel inhibitor of IκB kinase β.
IMD-0560
🥰Excellent
Purity: 99.51%
Catalog No. T15564Cas No. 439144-66-8
IMD-0560 is a novel inhibitor of IκB kinase β.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $37 | In Stock | |
| 5 mg | $88 | In Stock | |
| 10 mg | $142 | In Stock | |
| 25 mg | $257 | In Stock | |
| 50 mg | $386 | In Stock | |
| 100 mg | $530 | In Stock | |
| 200 mg | $729 | In Stock |
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Purity:99.51%
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Product Introduction
Bioactivity
Chemical Properties
| Description | IMD-0560 is a novel inhibitor of IκB kinase β. |
| In vitro | IMD-0560 inhibits TNFα-caused transcriptional activity. Pretreatment with IMD-0560 suppresses both IκBα degradation and p65 phosphorylation induced by TNFα and also strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression. |
| In vivo | Compare to the control groups, zygoma destruction is obviously suppressed in the IMD-0560-treated groups. In the IMD-0560-treated groups, the tumor size is decreased in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560. The inhibitory effect of each treatment on zygoma destruction is similar, although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group. |
| Molecular Weight | 428.12 |
| Formula | C15H8BrF6NO2 |
| Cas No. | 439144-66-8 |
| Smiles | Oc1ccc(Br)cc1C(=O)Nc1cc(ccc1C(F)(F)F)C(F)(F)F |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 50 mg/mL (116.79 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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