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Anti-MERTK/Mer Antibody (2J614)
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Catalog No. TMAH-00746
Alias Tyro12, RP38, MGC133349, MERTK, MER, c-mer, c-Eyk
Anti-MERTK/Mer Antibody (2J614) is an antibody targeting MERTK/Mer. Anti-MERTK/Mer Antibody (2J614) can be used in ELISA.
Anti-MERTK/Mer Antibody (2J614)
Anti-MERTK/Mer Antibody (2J614)
😃Good
Catalog No. TMAH-00746Alias Tyro12, RP38, MGC133349, MERTK, MER, c-mer, c-Eyk
Anti-MERTK/Mer Antibody (2J614) is an antibody targeting MERTK/Mer. Anti-MERTK/Mer Antibody (2J614) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Monoclonal Application: ELISA Reactivity: Human |
| Alias | Tyro12, RP38, MGC133349, MERTK, MER, c-mer, c-Eyk |
| Ig Type | Human IgG4(S228P) |
| Clone | 2J614 |
| Reactivity | Human |
| Verified Activity | The Binding Activity of MERTK with anti-MERTK antibody. Activity: Measured by its binding ability in a functional ELISA. Immobilized MERTK at 2 μg/mL can bind anti-MERTK antibody(TMAH-00746), the EC50 is 41.31-72.08 ng/mL. |
| Application | ELISA |
| Antibody Type | Monoclonal |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human MERTK Protein |
| Antigen Species | Human |
| Gene ID | 10461 |
| Uniprot ID | |
| Biology Area | Neuroscience, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
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