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Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488)
🥰Excellent
Catalog No. TMAY-03735H
Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488) is a HRP-conjugated Mouse antibody targeting NGAL/Lipocalin-2. Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488) can be used in ELISA.
Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488)
Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488)
🥰Excellent
Catalog No. TMAY-03735H
Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488) is a HRP-conjugated Mouse antibody targeting NGAL/Lipocalin-2. Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488) can be used in ELISA.
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Chemical Properties
| Description | Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488) is a HRP-conjugated Mouse antibody targeting NGAL/Lipocalin-2. Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG2a |
| Clone | 4O488 |
| Reactivity | Rat |
| Application | ELISA |
| Recommended Dose | ELISA: 0.1-1 μg/mL |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat NGAL / LCN2 / Lipocalin-2 (rR NGAL / LCN2 / Lipocalin-2; TMPY-02316; P30152; Met1-Asn198). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells, like kidney tubular cells, may produce NGAL in response to various insults. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein that specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute-phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, esophagus, brain) in humans. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival, and morphogenesis. |
| Conjucates | HRP |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Rat NGAL / LCN2 / Lipocalin-2 Protein (TMPY-02316) |
| Antigen Species | Rat |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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