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Vindoline

Name: Vindoline
Brand: TargetMol
SKU: T2773
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2773Cas No. 2182-14-1

Vindoline is an indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly.

Vindoline

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Purity: 99.89%

Catalog No. T2773Cas No. 2182-14-1

Vindoline is an indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$33	In Stock	In Stock
10 mg	$54	In Stock	In Stock
25 mg	$96	In Stock	In Stock
50 mg	$139	In Stock	-
100 mg	$198	In Stock	-
1 mL x 10 mM (in DMSO)	$36	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Vindoline AI Summary

Vindoline exhibits growth inhibition activity on various human tumor cell lines, as demonstrated by the NCI human tumor cell line growth inhibition assay. The compound shows GI50 values ranging from 14,521.12 nM to 199,986.19 nM across a variety of cancer cell lines including renal, lung, leukemia, melanoma, ovarian, and colon cell lines, suggesting its potential bioactivity against a wide range of cancer types. Additionally, Vindoline induces glucose-stimulated insulin secretion in mouse MIN6 cells with an EC50 value of 50,200.0 nM, indicating its potency in stimulating this biological response..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Vindoline is an indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly.

Chemical Properties

Molecular Weight	456.53
Formula	C₂₅H₃₂N₂O₆
Cas No.	2182-14-1
Smiles	CC[C@@]12C=CCN3CC[C@@]4([C@H]13)C(N(C)c1cc(OC)ccc41)[C@](O)([C@@H]2OC(C)=O)C(=O)OC
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (98.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1904 mL	10.9522 mL	21.9044 mL	109.5218 mL
5 mM	0.4381 mL	2.1904 mL	4.3809 mL	21.9044 mL
10 mM	0.2190 mL	1.0952 mL	2.1904 mL	10.9522 mL
20 mM	0.1095 mL	0.5476 mL	1.0952 mL	5.4761 mL
50 mM	0.0438 mL	0.2190 mL	0.4381 mL	2.1904 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc