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Anti-GCHFR Polyclonal Antibody
Catalog No. TMAB-06383 Copy Product Info
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Anti-GCHFR Polyclonal Antibody is a Rabbit antibody targeting GCHFR. Anti-GCHFR Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-GCHFR Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-06383
Anti-GCHFR Polyclonal Antibody is a Rabbit antibody targeting GCHFR. Anti-GCHFR Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-GCHFR Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-GCHFR Polyclonal Antibody is a Rabbit antibody targeting GCHFR. Anti-GCHFR Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse,Chicken,Pig,Cow) |
| Verified Activity | Paraformaldehyde-fixed, paraffin embedded (rat liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (GCHFR) Polyclonal Antibody, Unconjugated (TMAB-06383) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Nucleus membrane. Cytoplasm; cytosol. |
| Tissue Specificity | In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level). |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | GTP cyclohydrolase I feedback regulatory protein (GFRP) is encoded by the gene GCHFR. GFRP mediates feedback inhibition of GTP cyclohydrolase I activity by tetrahydrobiopterin. GFRP also acts as a mediator for the stimulatory effect of phenylalanine on enzyme activity. L-phenylalanine reverses this inhibition. The molecular weight of GFRP is approximately 9.5kDa although cross-linking experiments have shown that GFRP is usually found as a homodimer or as a pentamer. 15q15. |
| Immunogen | KLH conjugated synthetic peptide: human GCHFR |
| Antigen Species | Human |
| Gene Name | GCHFR |
| Gene ID | |
| Protein Name | GTP cyclohydrolase 1 feedback regulatory protein |
| Uniprot ID | |
| Function | Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. |
| Molecular Weight | Theoretical: 10 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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