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Alosetron hydrochloride
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Catalog No. T2525Cas No. 122852-69-1
Alias Lotronex, GR 68755X, GR 68755C, GR 68755
Alosetron hydrochloride (GR 68755) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system, particularly on enteric and nociceptive sensory neurons, thereby affecting the regulation of visceral pain, decreasing gastrointestinal contraction and motility, and decreasing gastrointestinal secretions.
Alosetron hydrochloride
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Purity: 99.90%
Catalog No. T2525Alias Lotronex, GR 68755X, GR 68755C, GR 68755Cas No. 122852-69-1
Alosetron hydrochloride (GR 68755) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system, particularly on enteric and nociceptive sensory neurons, thereby affecting the regulation of visceral pain, decreasing gastrointestinal contraction and motility, and decreasing gastrointestinal secretions.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $31 | In Stock | In Stock | |
| 25 mg | $71 | In Stock | In Stock | |
| 50 mg | $115 | In Stock | In Stock | |
| 100 mg | $186 | - | In Stock | |
| 200 mg | $276 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.90%
Appearance:Solid
Color:White
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Product Introduction
Alosetron hydrochloride AI Summary
Alosetron hydrochloride demonstrates a wide range of bioactivities, notably as an inhibitor in several assay types including Choline Transporter, RanGTP induced Rango, Human Flap endonuclease 1, Sentrin-Specific Protease 8, DNA re-replication in SW480 colon adenocarcinoma cells, ERG Ets/DNA interaction, human tyrosyl-DNA phosphodiesterase 1 (TDP1), USP1/UAF1, Caspase 6, and entry blocking of Ebola Virus across multiple screens and channels. It exhibits potency in the nanomolar to micromolar range in these assays. Additionally, Alosetron hydrochloride shows antiviral activity against SARS-CoV-2 in Vero E6 and Caco-2 cells, with specific inhibition indices and percentages at various concentrations and time points, including a 10.15% inhibition of the SARS-CoV-2 3CL-Pro protease at 20µM. Although it demonstrates low inhibition of cell viability in SARS-CoV-2 infected Vero E6 cells, it does present antiviral inhibition of cytotoxicity at low percentages, such as 0.05% in Vero-6 cells at 10µM. Furthermore, Alosetron hydrochloride exhibits antifungal activity against Candida albicans and Cryptococcus neoformans, albeit with variable inhibition rates. It also shows antibacterial activities against multiple strains including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus MRSA, with inhibition rates ranging from approximately 8.61% to 15.86%..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Alosetron hydrochloride (GR 68755) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system, particularly on enteric and nociceptive sensory neurons, thereby affecting the regulation of visceral pain, decreasing gastrointestinal contraction and motility, and decreasing gastrointestinal secretions. |
| Synonyms | Lotronex, GR 68755X, GR 68755C, GR 68755 |
| Molecular Weight | 330.81 |
| Formula | C17H19ClN4O |
| Cas No. | 122852-69-1 |
| Smiles | Cl.Cc1nc[nH]c1CN1CCc2c(C1=O)c1ccccc1n2C |
| Relative Density. | 1.34g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 8.57 mg/mL (25.91 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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