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3,5-Dimethoxyphenol (Alias: Phloroglucinol dimethyl ether)

Name: 3,5-Dimethoxyphenol
Brand: TargetMol
SKU: T7438
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T7438 Copy Product Info

Purity: 98%

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3,5-Dimethoxyphenol (Phloroglucinol dimethyl ether) as a marker of Taxus poisoning, being present in all species of Taxus. It has potent tyrosinase-inhibiting activity.

3,5-Dimethoxyphenol

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Catalog No. T7438

Alias Phloroglucinol dimethyl ether

3,5-Dimethoxyphenol (Phloroglucinol dimethyl ether) as a marker of Taxus poisoning, being present in all species of Taxus. It has potent tyrosinase-inhibiting activity.

Cas No. 500-99-2

Pack Size	Price	USA Stock	Global Stock	Quantity
1 g	$29	-	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98%

Appearance:solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

3,5-Dimethoxyphenol AI Summary

3,5-Dimethoxyphenol shows a bioactivity of binding affinity to beta cyclodextrin, with a logarithmic binding constant of 2.34. It also exhibits protective effects against AfB1-induced toxicity in human HepG2 cells, as evidenced by a 37.0% live cell area at a 5 µM concentration after 48 hours, assessed using calcein-AM/Hoechst 33342 staining-based high-content imaging analysis..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	3,5-Dimethoxyphenol (Phloroglucinol dimethyl ether) as a marker of Taxus poisoning, being present in all species of Taxus. It has potent tyrosinase-inhibiting activity.
Synonyms	Phloroglucinol dimethyl ether

Chemical Properties

Molecular Weight	154.16
Formula	C₈H₁₀O₃
Cas No.	500-99-2
Smiles	COC1=CC(OC)=CC(O)=C1
Relative Density.	1.134 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (356.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.4868 mL	32.4338 mL	64.8677 mL	324.3383 mL
5 mM	1.2974 mL	6.4868 mL	12.9735 mL	64.8677 mL
10 mM	0.6487 mL	3.2434 mL	6.4868 mL	32.4338 mL
20 mM	0.3243 mL	1.6217 mL	3.2434 mL	16.2169 mL
50 mM	0.1297 mL	0.6487 mL	1.2974 mL	6.4868 mL
100 mM	0.0649 mL	0.3243 mL	0.6487 mL	3.2434 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc