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NB-360

Name: NB-360
Brand: TargetMol
SKU: T12188
Price: 112 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12188Cas No. 1262857-73-7

NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D.

NB-360

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Purity: 99.72%

Catalog No. T12188Cas No. 1262857-73-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$112	-	In Stock
5 mg	$238	-	In Stock
10 mg	$353	-	In Stock
25 mg	$567	-	In Stock
50 mg	$768	-	In Stock
100 mg	$987	-	In Stock
500 mg	$1,980	-	In Stock
1 mL x 10 mM (in DMSO)	$262	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.72%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D.
Targets&IC50	BACE1 (mouse , human):5 nM , BACE2:6 nM
In vivo	NB-360 blocks the progression of Aβ deposition in the brains of APP transgenic mice, a model for amyloid pathology. Almost complete reduction of Aβ was achieved also in rats and in dogs. NB-360 stops accumulation of activated inflammatory cells in the brains of APP transgenic mice. Upon chronic treatment of APP transgenic mice, patches of grey hairs appeared[2].

Chemical Properties

Molecular Weight	449.4
Formula	C₂₁H₁₉F₄N₅O₂
Cas No.	1262857-73-7
Smiles	Cc1cc(cnc1C(=O)Nc1ccc(F)c(c1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (100.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2252 mL	11.1259 mL	22.2519 mL	111.2595 mL
5 mM	0.4450 mL	2.2252 mL	4.4504 mL	22.2519 mL
10 mM	0.2225 mL	1.1126 mL	2.2252 mL	11.1259 mL
20 mM	0.1113 mL	0.5563 mL	1.1126 mL	5.5630 mL
50 mM	0.0445 mL	0.2225 mL	0.4450 mL	2.2252 mL
100 mM	0.0223 mL	0.1113 mL	0.2225 mL	1.1126 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc