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NB-360

Name: NB-360
Brand: TargetMol
SKU: T12188
Price: 112 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12188Cas No. 1262857-73-7

NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D.

NB-360

🥰Excellent

Purity: 99.72%

Catalog No. T12188Cas No. 1262857-73-7

Pack Size	Price	Availability
1 mg	$112	In Stock
5 mg	$238	In Stock
10 mg	$353	In Stock
25 mg	$567	In Stock
50 mg	$768	In Stock
100 mg	$987	In Stock
500 mg	$1,980	In Stock
1 mL x 10 mM (in DMSO)	$262	In Stock

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Batch Information

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Purity:99.72%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D.
Targets&IC50	BACE1 (mouse , human):5 nM , BACE2:6 nM
In vivo	NB-360 blocks the progression of Aβ deposition in the brains of APP transgenic mice, a model for amyloid pathology. Almost complete reduction of Aβ was achieved also in rats and in dogs. NB-360 stops accumulation of activated inflammatory cells in the brains of APP transgenic mice. Upon chronic treatment of APP transgenic mice, patches of grey hairs appeared[2].

Chemical Properties

Molecular Weight	449.4
Formula	C₂₁H₁₉F₄N₅O₂
Cas No.	1262857-73-7
Smiles	Cc1cc(cnc1C(=O)Nc1ccc(F)c(c1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (100.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2252 mL	11.1259 mL	22.2519 mL	111.2595 mL
5 mM	0.4450 mL	2.2252 mL	4.4504 mL	22.2519 mL
10 mM	0.2225 mL	1.1126 mL	2.2252 mL	11.1259 mL
20 mM	0.1113 mL	0.5563 mL	1.1126 mL	5.5630 mL
50 mM	0.0445 mL	0.2225 mL	0.4450 mL	2.2252 mL
100 mM	0.0223 mL	0.1113 mL	0.2225 mL	1.1126 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc