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Sinapaldehyde

Name: Sinapaldehyde
Brand: TargetMol
SKU: TN2281
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN2281Cas No. 4206-58-0

Alias trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde

Sinapaldehyde (trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde) is a natural product. Sinapaldehyde exhibits moderate antibacterial against Methicillin resistant S. aureus (MRSA) and E. coli with MIC values of 128 and 128 μg/mL.

Sinapaldehyde

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Purity: 99.99%

Catalog No. TN2281Alias trans-3,5-Dimethoxy-4-hydroxy cinnamaldehydeCas No. 4206-58-0

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$37	In Stock	In Stock
50 mg	$50	-	In Stock
100 mg	$68	-	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Sinapaldehyde AI Summary

Sinapaldehyde shows activity against caspase-mediated apoptosis in mouse L1210 cells and demonstrates significant cytotoxicity with log(1/ID50) values of 2.6 and 4.25, respectively. In human cell lines, it exhibits cytotoxicity with IC50 values ranging from 33,000 nM to over 100,000 nM after 72 hours as measured by the MTT assay. Specifically, it has cytostatic activity against U373 cells, achieving 50% growth inhibition at its MTT assay-related IC50, and induces cell death in U373 cells, evidenced by morphological changes at a 2% activity level at its IC50 after 72 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Sinapaldehyde (trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde) is a natural product. Sinapaldehyde exhibits moderate antibacterial against Methicillin resistant S. aureus (MRSA) and E. coli with MIC values of 128 and 128 μg/mL.
Synonyms	trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde

Chemical Properties

Molecular Weight	208.21
Formula	C₁₁H₁₂O₄
Cas No.	4206-58-0
Smiles	COc1cc(\C=C\C=O)cc(OC)c1O
Relative Density.	1.195 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (264.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8028 mL	24.0142 mL	48.0284 mL	240.1422 mL
5 mM	0.9606 mL	4.8028 mL	9.6057 mL	48.0284 mL
10 mM	0.4803 mL	2.4014 mL	4.8028 mL	24.0142 mL
20 mM	0.2401 mL	1.2007 mL	2.4014 mL	12.0071 mL
50 mM	0.0961 mL	0.4803 mL	0.9606 mL	4.8028 mL
100 mM	0.0480 mL	0.2401 mL	0.4803 mL	2.4014 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc