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Anti-MGLUR5 Polyclonal Antibody

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Catalog No. TMAB-08795

Anti-MGLUR5 Polyclonal Antibody is a Rabbit antibody targeting MGLUR5. Anti-MGLUR5 Polyclonal Antibody can be used in WB.

Anti-MGLUR5 Polyclonal Antibody

Anti-MGLUR5 Polyclonal Antibody

😃Good
Catalog No. TMAB-08795
Anti-MGLUR5 Polyclonal Antibody is a Rabbit antibody targeting MGLUR5. Anti-MGLUR5 Polyclonal Antibody can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2227-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5297-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-MGLUR5 Polyclonal Antibody is a Rabbit antibody targeting MGLUR5. Anti-MGLUR5 Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human,Mouse,Rat (predicted:Chicken,Cow,Horse,Sheep,Monkey)
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCell Membrane
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundGlutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: Ionotropic receptors, and metabotropic receptors (mGluRs). Metabotropic Glutamate Receptor 5b (GRM5) activity is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The metabotropic glutamate receptor type 5 (mGlu5) is expressed in two splice variants, mGlu5a and mGlu5b, which differ in that mGlu5b has a 33-amino acid insert in the intracellular C-terminal domain. This receptor subtype is highly regulated, with higher levels found in developing animals.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human MGLUR5
Antigen Species
Human
Gene Name
GRM5
Gene ID
2915
Protein Name
Metabotropic glutamate receptor 5
Uniprot ID
P41594
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteKns) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
Chemical Properties
Molecular WeightTheoretical: 130 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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