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Methyl indole-3-carboxylate

Name: Methyl indole-3-carboxylate
Brand: TargetMol
SKU: T5868
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5868Cas No. 942-24-5

Alias Methyl 3-indolecarboxylate

Methyl indole-3-carboxylate (Methyl 3-indolecarboxylate) is a natural product isolated from Heracleum candicans.

Methyl indole-3-carboxylate

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Purity: 99.41%

Catalog No. T5868Alias Methyl 3-indolecarboxylateCas No. 942-24-5

Methyl indole-3-carboxylate (Methyl 3-indolecarboxylate) is a natural product isolated from Heracleum candicans.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.41%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Methyl indole-3-carboxylate AI Summary

Methyl indole-3-carboxylate exhibits significant bioactivity across multiple biological targets. It demonstrates fungicidal activity against Cryphonectria parasitica, with increasing inhibition of fungal growth observed at higher concentrations of 12.5 µg, 25 µg, 50 µg, and 100 µg, corresponding to inhibition zone diameters of 4.0 mm, 6.0 mm, 8.0 mm, and 11.0 mm, respectively, over 7 days. The compound also shows antimicrobial activity against Nocardia sp. 43069, with a minimum inhibitory concentration (MIC) of 33.3 µg/mL but lacks significant effects on other strains at MIC > 66.6 µg/mL. Despite its antimicrobial properties, Methyl indole-3-carboxylate displays high cytotoxicity with an IC50 greater than 56800.0 nM against various human cell lines. It inhibits His tagged recombinant CBP with an IC50 of 99000.0 nM, and His tagged recombinant BRD4 bromodomain 1 with an IC50 greater than 100000.0 nM, showcasing a selectivity ratio of greater than 1.0. Additionally, the compound functions as an inverse agonist at the Nurr1 LBD expressed in HEK293T cells with an IC50 of 48000.0 nM, demonstrating an activity of 0.31% relative to control, indicative of its potency in this role. Furthermore, it exhibits inverse agonist activity at Nurr1, with an IC50 of 48000.0 nM and 31.0% activity relative to control..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Methyl indole-3-carboxylate (Methyl 3-indolecarboxylate) is a natural product isolated from Heracleum candicans.
Synonyms	Methyl 3-indolecarboxylate

Chemical Properties

Molecular Weight	175.18
Formula	C₁₀H₉NO₂
Cas No.	942-24-5
Smiles	COC(=O)C1=CNC2=CC=CC=C12
Relative Density.	1.253 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (313.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.7084 mL	28.5421 mL	57.0841 mL	285.4207 mL
5 mM	1.1417 mL	5.7084 mL	11.4168 mL	57.0841 mL
10 mM	0.5708 mL	2.8542 mL	5.7084 mL	28.5421 mL
20 mM	0.2854 mL	1.4271 mL	2.8542 mL	14.2710 mL
50 mM	0.1142 mL	0.5708 mL	1.1417 mL	5.7084 mL
100 mM	0.0571 mL	0.2854 mL	0.5708 mL	2.8542 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc