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Chromafenozide

Name: Chromafenozide
Brand: TargetMol
SKU: T13612
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13612Cas No. 143807-66-3

Alias ANS118

Chromafenozide (ANS118) (ANS118) is a lepidopteran insecticide with the effect of controlling various lepidopteran pests.

Chromafenozide

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Purity: 99.15%

Catalog No. T13612Alias ANS118Cas No. 143807-66-3

Chromafenozide (ANS118) (ANS118) is a lepidopteran insecticide with the effect of controlling various lepidopteran pests.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$53	In Stock	In Stock
5 mg	$126	In Stock	In Stock
10 mg	$181	In Stock	In Stock
25 mg	$313	In Stock	In Stock
50 mg	$455	In Stock	In Stock
100 mg	$639	In Stock	In Stock
200 mg	$882	-	In Stock
1 mL x 10 mM (in DMSO)	$147	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.15%

Appearance:Solid

Color:White

Resource Download

COA HPLC LCMS HNMR

Product Introduction

Chromafenozide AI Summary

Chromafenozide is a hydrophobic compound with a partition coefficient log P of 2.7 and LogD = 2.7 in Octanol-buffer, indicative of its lipophilicity. It exhibits a permeability coefficient of 16.69 x 10^-6 cm/s through an artificial membrane in the presence of an unstirred water layer, but shows very low apparent permeability with log Papp = -4.78. The compound also has a low dissociation constant (pKa of 0.0 at pH 7.3) and demonstrates a 12.0% retention on the membrane in permeability experiments, suggesting some degree of membrane interaction. Biologically, Chromafenozide demonstrates significant insecticidal activity, exhibiting strong stomach toxicity and contact toxicity against various insect species, including European corn borer, diamondback moth, Spodoptera exigua, Oriental armyworm, Culex pipiens pallens, Mythimna separata, Plutella xylostella, Ostrinia nubilalis, and Helicoverpa armigera. It shows potent larvicidal activity and acts as an agonist at the ecdysone receptor in Spodoptera littoralis and Bombyx mori cells, highlighting its potential as an insecticidal agent. In addition to its insecticidal properties, Chromafenozide exhibits some antiviral activities. It shows a 9.17% inhibition of SARS-CoV-2 3CL-Pro protease activity at a concentration of 20 µM and inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM concentration, with an inhibition rate of 0.08% after 48 hours of exposure. These features suggest that Chromafenozide could be of interest for its multifaceted bioactivities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Chromafenozide (ANS118) (ANS118) is a lepidopteran insecticide with the effect of controlling various lepidopteran pests.
Synonyms	ANS118

Chemical Properties

Molecular Weight	394.51
Formula	C₂₄H₃₀N₂O₃
Cas No.	143807-66-3
Smiles	Cc1cc(C)cc(c1)C(=O)N(NC(=O)c1ccc2OCCCc2c1C)C(C)(C)C
Relative Density.	1.129g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (633.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5348 mL	12.6739 mL	25.3479 mL	126.7395 mL
5 mM	0.5070 mL	2.5348 mL	5.0696 mL	25.3479 mL
10 mM	0.2535 mL	1.2674 mL	2.5348 mL	12.6739 mL
20 mM	0.1267 mL	0.6337 mL	1.2674 mL	6.3370 mL
50 mM	0.0507 mL	0.2535 mL	0.5070 mL	2.5348 mL
100 mM	0.0253 mL	0.1267 mL	0.2535 mL	1.2674 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc