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Benzamidine hydrochloride

Name: Benzamidine hydrochloride
Brand: TargetMol
SKU: T8362
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8362Cas No. 1670-14-0

Alias Benzamidine HCl

Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively).

Benzamidine hydrochloride

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Purity: 99.97%

Catalog No. T8362Alias Benzamidine HClCas No. 1670-14-0

Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively).

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$40	-	In Stock
1 g	$56	-	In Stock
2 g	$79	-	In Stock
5 g	$129	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Appearance:Solid

Color:White

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COA LCMS HPLC HNMR

Product Introduction

Benzamidine hydrochloride AI Summary

Benzamidine hydrochloride shows bioactivity as an inhibitor of multiple targets. It acts as an inhibitor of f11a with an IC50 value of 120000.0 nM, indicating its potency in inhibiting f11a activity at this concentration. Additionally, it demonstrates potent bioactivity as an inhibitor of Bloom's syndrome helicase (BLM) with a potency of 89.1 nM in confirmatory assays. It also exhibits significant inhibition of the Human hERG Channel with a potency of 31622.8 nM and inhibits human recombinant KLK5 enzyme activity with an IC50 value of 501187.23 nM, as measured using a fluorescence-based assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively).
Targets&IC50	Plasmin:350µM(Ki) , Trypsin:35µM(Ki) , Thrombin:220 µM(Ki)
Synonyms	Benzamidine HCl

Chemical Properties

Molecular Weight	156.61
Formula	C₇H₉ClN₂
Cas No.	1670-14-0
Smiles	Cl.NC(=N)C1=CC=CC=C1
Relative Density.	1.09 g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 142.8 mg/mL (911.82 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (6.39 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.3853 mL	31.9264 mL	63.8529 mL	319.2644 mL
5 mM	1.2771 mL	6.3853 mL	12.7706 mL	63.8529 mL
10 mM	0.6385 mL	3.1926 mL	6.3853 mL	31.9264 mL
20 mM	0.3193 mL	1.5963 mL	3.1926 mL	15.9632 mL
50 mM	0.1277 mL	0.6385 mL	1.2771 mL	6.3853 mL
100 mM	0.0639 mL	0.3193 mL	0.6385 mL	3.1926 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc