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Apilimod

Name: Apilimod
Brand: TargetMol
SKU: T2018
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2018Cas No. 541550-19-0

Alias STA 5326

Apilimod (STA 5326) inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.

Apilimod

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Purity: 99.89%

Catalog No. T2018Alias STA 5326Cas No. 541550-19-0

Apilimod (STA 5326) inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$43	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$81	In Stock	In Stock
50 mg	$97	In Stock	In Stock
100 mg	$158	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Color:White

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COA HPLC LCMS HNMR

Product Introduction

Apilimod AI Summary

Apilimod exhibits potent antiviral activity against SARS-CoV-2, with an EC50 value of 23.0 nM in a high-content imaging assay using Vero E6 cells infected with the USA-WA1/2020 isolate after 24 hours. Additionally, its ability to inhibit SARS-CoV-2 induced cytotoxicity has been demonstrated in multiple cell lines, including Caco-2 cells, where it showed an inhibition rate of 8.48% at 10 µM after 48 hours, and in Vero E6 cells, where it exhibited an inhibition rate of 5.69% at 10 µM after 48 hours. The compound also inhibits the SARS-CoV-2 3CL-Pro protease with an inhibition rate of 10.54% at 20 µM. Further assays indicate inhibition of viral growth with an IC50 of less than 80 nM in Vero E6 cells and 7 nM in A549-ACE2 cells. In addition to its antiviral properties, Apilimod inhibits human PIKFYVE with IC50 values ranging from 0.309 nM to 15.0 nM, and demonstrates HDAC6 inhibition with modest rates of 1.14% to 4.44%. It also shows significant binding affinity to human wild type partial length PIKFYVE with a dissociation constant of 0.075 nM. However, it exhibits cytotoxicity against Vero E6 cells at concentrations above 1000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Apilimod (STA 5326) inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.
Targets&IC50	PIKfyve:14 nM
Synonyms	STA 5326

Chemical Properties

Molecular Weight	418.49
Formula	C₂₃H₂₆N₆O₂
Cas No.	541550-19-0
Smiles	Cc1cccc(\C=N\Nc2cc(nc(OCCc3ccccn3)n2)N2CCOCC2)c1
Relative Density.	1.24

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (477.91 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3895 mL	11.9477 mL	23.8954 mL	119.4772 mL
5 mM	0.4779 mL	2.3895 mL	4.7791 mL	23.8954 mL
10 mM	0.2390 mL	1.1948 mL	2.3895 mL	11.9477 mL
20 mM	0.1195 mL	0.5974 mL	1.1948 mL	5.9739 mL
50 mM	0.0478 mL	0.2390 mL	0.4779 mL	2.3895 mL
100 mM	0.0239 mL	0.1195 mL	0.2390 mL	1.1948 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc