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Cycloguanil hydrochloride

Name: Cycloguanil hydrochloride
Brand: TargetMol
SKU: T5420
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5420Cas No. 152-53-4

Alias Chloroguanide Triazine

Cycloguanil hydrochloride (Chloroguanide Triazine) is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms, respectively).

Cycloguanil hydrochloride

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Purity: 98.72%

Catalog No. T5420Alias Chloroguanide TriazineCas No. 152-53-4

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$31	In Stock	In Stock
10 mg	$45	In Stock	In Stock
25 mg	$74	In Stock	In Stock
50 mg	$106	In Stock	In Stock
100 mg	$147	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.72%

Appearance:Solid

Color:White

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COA LCMS HNMR HPLC

Product Introduction

Cycloguanil hydrochloride AI Summary

Cycloguanil hydrochloride exhibits potent antimalarial activity across various Plasmodium species and stages. In animal models, it demonstrates a dose-dependent increase in mean survival time (MST) against Plasmodium berghei, with higher doses resulting in longer MST. It also shows substantial efficacy against trophozoite-induced and sporozoite-induced infections with MSTs of 21.6 days at 80 mg/kg, 13.4 days at 40 mg/kg, and 7.9 days at 20 mg/kg in murine models. Additionally, Cycloguanil hydrochloride exhibits inhibitory activity against Plasmodium yoelii schizont stages with an IC50 of 2.56 nM and significant effects on human hepatocellular carcinoma cells with a CC50 of 27360.0 nM. It also acts against Plasmodium falciparum, showing strong inhibition of both drug-susceptible and drug-resistant strains with EC50 values of 0.986 nM and 884.0 nM, respectively. Furthermore, the compound is a potent inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1) and demonstrates moderate activity against Lassa and Marburg viruses. Lastly, it shows promising results in decreasing schizont sizes in liver-stage malaria assays, supporting its multifaceted antimalarial properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cycloguanil hydrochloride (Chloroguanide Triazine) is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms, respectively).
Synonyms	Chloroguanide Triazine

Chemical Properties

Molecular Weight	288.18
Formula	C₁₁H₁₄ClN₅.ClH
Cas No.	152-53-4
Smiles	Cl.CC1(C)N=C(N)N=C(N)N1c1ccc(Cl)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (69.4 mM), Sonication is recommended.

H2O: 5 mg/mL (17.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4701 mL	17.3503 mL	34.7005 mL	173.5027 mL
5 mM	0.6940 mL	3.4701 mL	6.9401 mL	34.7005 mL
10 mM	0.3470 mL	1.7350 mL	3.4701 mL	17.3503 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1735 mL	0.8675 mL	1.7350 mL	8.6751 mL
50 mM	0.0694 mL	0.3470 mL	0.6940 mL	3.4701 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc