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6-Chloropurine riboside

Name: 6-Chloropurine riboside
Brand: TargetMol
SKU: T7826
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7826Cas No. 5399-87-1

6-Chloropurine riboside (6-CPR) is a purine nucleoside analog that has been found to have a wide range of biological activities. It inhibits the growth of tumor cells and induces apoptosis. It has also been shown to have anti-inflammatory, antiviral and antifungal properties. It has also been found to be neuroprotective and has been used in the treatment of neurological disorders.

6-Chloropurine riboside

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Purity: 96.84%

Catalog No. T7826Cas No. 5399-87-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:96.84%

Appearance:solid

Color:White

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COA HNMR LCMS

Product Introduction

6-Chloropurine riboside AI Summary

6-Chloropurine riboside exhibits strong bioactivity with a molar potency ratio of 0.023. It shows in vitro antiviral activity against a variety of viruses, including HSV-1, vaccinia virus (VV), parainfluenza type 3 (Para 3), vesicular stomatitis virus (VSV), and Coxsackievirus B1 (COXB1). Specific virus ratings range from 0.3 to 1.8, reflecting its broad-spectrum antiviral potential. Notably, the compound inhibits the cytopathogenic effects of HSV type 1 strain HF and vaccinia virus with IC50 values of 13.8 µg/mL and 13.0 µg/mL, respectively. Against SARS-CoV Frankfurt1 in Vero E6 cells, 6-Chloropurine riboside has an IC50 of 48700.0 nM and a CC50 of 279000.0 nM, resulting in a selectivity index of 5.7. It also inhibits HCV replication in Huh7 cells with an EC50 of 31000.0 nM and shows a CC50 greater than 200000.0 nM, yielding a selectivity index above 6.5. Beyond antiviral activity, 6-Chloropurine riboside functions as a modulator of Lamin A splicing and inhibits various biological targets, including Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase), USP1/UAF1, and human tyrosyl-DNA phosphodiesterase 1 (TDP1) both with and without CPT. It also inhibits Marburg Virus binding or entry into cells with potencies ranging from 4610.9 nM to 100000.0 nM. Additionally, the compound inhibits the SARS-CoV 3CL protease, demonstrating an IC50 of 48700.0 nM in the relevant assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	286.6700
Formula	C₁₀H₁₁ClN₄O₄
Cas No.	5399-87-1
Smiles	OC[C@H]1O[C@@H](n2cnc3c(Cl)ncnc32)[C@H](O)[C@@H]1O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (95.93 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4883 mL	17.4417 mL	34.8833 mL	174.4166 mL
5 mM	0.6977 mL	3.4883 mL	6.9767 mL	34.8833 mL
10 mM	0.3488 mL	1.7442 mL	3.4883 mL	17.4417 mL
20 mM	0.1744 mL	0.8721 mL	1.7442 mL	8.7208 mL
50 mM	0.0698 mL	0.3488 mL	0.6977 mL	3.4883 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc