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APS6-45

Name: APS6-45
Brand: TargetMol
SKU: T8843
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8843Cas No. 2188236-41-9

APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.

APS6-45

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Purity: 99.39%

Catalog No. T8843Cas No. 2188236-41-9

APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$81	In Stock	In Stock
10 mg	$129	In Stock	In Stock
25 mg	$263	In Stock	In Stock
50 mg	$423	In Stock	In Stock
100 mg	$648	In Stock	In Stock
200 mg	$873	-	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.39%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
In vitro	APS6-45 (1 μM; 1 h) strongly inhibits RAS pathway activity signaling in human MTC cell lines TT and MZ-CRC-1[1].
In vivo	APS6-45 did not affect body weight of dosed(10 mg/kg) mice after 30 d.APS6-45 (0.1-160 mg/kg; a single p.o.) does not cause detectable toxic effects in mice[1].

Chemical Properties

Molecular Weight	548.39
Formula	C₂₃H₁₆F₈N₄O₃
Cas No.	2188236-41-9
Smiles	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(ccc3F)C(F)(C(F)(F)F)C(F)(F)F)cc2)ccn1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (437.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8235 mL	9.1176 mL	18.2352 mL	91.1760 mL
5 mM	0.3647 mL	1.8235 mL	3.6470 mL	18.2352 mL
10 mM	0.1824 mL	0.9118 mL	1.8235 mL	9.1176 mL
20 mM	0.0912 mL	0.4559 mL	0.9118 mL	4.5588 mL
50 mM	0.0365 mL	0.1824 mL	0.3647 mL	1.8235 mL
100 mM	0.0182 mL	0.0912 mL	0.1824 mL	0.9118 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc