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APS6-45

Name: APS6-45
Brand: TargetMol
SKU: T8843
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8843Cas No. 2188236-41-9

APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.

APS6-45

🥰Excellent

Purity: 99.39%

Catalog No. T8843Cas No. 2188236-41-9

APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.

Pack Size	Price	Availability
2 mg	$33	In Stock
5 mg	$81	In Stock
10 mg	$129	In Stock
25 mg	$263	In Stock
50 mg	$423	In Stock
100 mg	$648	In Stock
200 mg	$873	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Batch Information

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Purity:99.39%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
In vitro	APS6-45 (1 μM; 1 h) strongly inhibits RAS pathway activity signaling in human MTC cell lines TT and MZ-CRC-1[1].
In vivo	APS6-45 did not affect body weight of dosed(10 mg/kg) mice after 30 d.APS6-45 (0.1-160 mg/kg; a single p.o.) does not cause detectable toxic effects in mice[1].

Chemical Properties

Molecular Weight	548.39
Formula	C₂₃H₁₆F₈N₄O₃
Cas No.	2188236-41-9
Smiles	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(ccc3F)C(F)(C(F)(F)F)C(F)(F)F)cc2)ccn1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (437.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8235 mL	9.1176 mL	18.2352 mL	91.1760 mL
5 mM	0.3647 mL	1.8235 mL	3.6470 mL	18.2352 mL
10 mM	0.1824 mL	0.9118 mL	1.8235 mL	9.1176 mL
20 mM	0.0912 mL	0.4559 mL	0.9118 mL	4.5588 mL
50 mM	0.0365 mL	0.1824 mL	0.3647 mL	1.8235 mL
100 mM	0.0182 mL	0.0912 mL	0.1824 mL	0.9118 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc