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AZ9482

Name: AZ9482
Brand: TargetMol
SKU: T22264
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22264Cas No. 1825345-33-2

AZ9482 is a selective and potent inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent activity of centrosome declustering with EC50 of < 18 nM in HeLa cells.

AZ9482

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Purity: 99.86%

Catalog No. T22264Cas No. 1825345-33-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	In Stock	In Stock
5 mg	$133	In Stock	In Stock
10 mg	$215	In Stock	In Stock
25 mg	$409	In Stock	In Stock
50 mg	$595	In Stock	In Stock
100 mg	$866	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$143	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HPLC HNMR

Product Introduction

AZ9482 AI Summary

AZ9482 exhibits various bioactivities, prominently acting as a potent PARP inhibitor with IC50 values ranging from 1.0 nM to 640.0 nM in cellular and biochemical assays. Highlighting its potential as an anti-cancer agent, the compound displays cytotoxicity against human OCI-LY19 cells with an IC50 of 3.0 nM. Furthermore, it inhibits the TNSK1/2-activated Wnt pathway with an IC50 of 222.0 nM, indicating its role in modulating cellular signaling pathways. Additionally, AZ9482 induces centrosome declustering in various cancer cell lines, with EC50 values spanning from 3.0 nM to 123.0 nM. Pharmacokinetic profiles, including solubility, lipophilicity, clearance rates, and distribution volumes, suggest favorable drug-like properties and oral bioavailability in both rat and mouse models. Overall, AZ9482 shows promising bioactivity profiles that warrant further investigation for potential therapeutic applications, particularly in cancer treatment and PARP-related pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	450.49
Formula	C₂₆H₂₂N₆O₂
Cas No.	1825345-33-2
Smiles	O=C(N1CCN(CC1)c1ncccc1C#N)c1cccc(Cc2n[nH]c(=O)c3ccccc23)c1
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (277.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (7.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2198 mL	11.0990 mL	22.1981 mL	110.9903 mL
5 mM	0.4440 mL	2.2198 mL	4.4396 mL	22.1981 mL
10 mM	0.2220 mL	1.1099 mL	2.2198 mL	11.0990 mL
20 mM	0.1110 mL	0.5550 mL	1.1099 mL	5.5495 mL
50 mM	0.0444 mL	0.2220 mL	0.4440 mL	2.2198 mL
100 mM	0.0222 mL	0.1110 mL	0.2220 mL	1.1099 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc