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Anti-RIPK3 Antibody (8T623)
😃Good
Catalog No. TMAB-12267
Anti-RIPK3 Antibody (8T623) is a Mouse antibody targeting RIPK3. Anti-RIPK3 Antibody (8T623) can be used in WB.
Anti-RIPK3 Antibody (8T623)
Anti-RIPK3 Antibody (8T623)
😃Good
Catalog No. TMAB-12267
Anti-RIPK3 Antibody (8T623) is a Mouse antibody targeting RIPK3. Anti-RIPK3 Antibody (8T623) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-RIPK3 Antibody (8T623) is a Mouse antibody targeting RIPK3. Anti-RIPK3 Antibody (8T623) can be used in WB. |
| Ig Type | IgG1, k |
| Clone | 8T623 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Cytoplasm. Cell membrane. Mitochondrion (Potential). |
| Tissue Specificity | Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008] |
| Immunogen | Recombinant Protein: human RIPK3 |
| Antigen Species | Human |
| Gene Name | RIPK3 |
| Gene ID | |
| Protein Name | Receptor-interacting serine/threonine-protein kinase 3 |
| Uniprot ID | |
| Function | Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. |
| Molecular Weight | Theoretical: 57 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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