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Cucurbitacin IIA

Name: Cucurbitacin IIA
Brand: TargetMol
SKU: T3S1471
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3S1471Cas No. 58546-34-2

Alias Hemslecin A, Dihydrocucurbitacin Q1, Curcurbitacin IIA

1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a novel class of anti-cancer drug in suppression of cancer cell expansion by disrupting the actin cytoskeleton and directing the cell to undergo PARP-mediated apoptosis through the inhibition of survivin downstream of JAK2/STAT3.

Cucurbitacin IIA

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Purity: 99.87%

Catalog No. T3S1471Alias Hemslecin A, Dihydrocucurbitacin Q1, Curcurbitacin IIACas No. 58546-34-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$213	In Stock	In Stock
50 mg	$319	-	In Stock
100 mg	$475	-	In Stock
500 mg	$987	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Cucurbitacin IIA AI Summary

Cucurbitacin IIA exhibits antiviral activity against HBV infected in human HepG2.2.15 cells by inhibiting viral DNA replication with an IC50 of 11200 nM, although it shows low selectivity indices for inhibiting viral e antigen and surface antigen production, with IC50 values greater than 66200 nM. Additionally, it demonstrates cytotoxic effects on human HepG2.2.15 cells with a CC50 of 66200 nM. The compound also exerts cytotoxic activity against human cancer cell lines H460, SW620, and COLO205, with IC50 values of 11.53 µg/mL, 1.11 µg/mL, and 1.09 µg/mL, respectively, as determined by the MTT assay after 48 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

Hemslecin A, Dihydrocucurbitacin Q1, Curcurbitacin IIA

Chemical Properties

Molecular Weight	562.73
Formula	C₃₂H₅₀O₈
Cas No.	58546-34-2
Smiles	[H][C@@]1([C@H](O)C[C@@]2(C)[C@]3([H])CC=C4[C@@]([H])(C[C@H](O)[C@@H](O)C4(C)C)[C@]3(C)C(=O)C[C@]12C)[C@@](C)(O)C(=O)CCC(C)(C)OC(C)=O
Relative Density.	1.22 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 91 mg/mL (161.71 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7771 mL	8.8853 mL	17.7705 mL	88.8526 mL
5 mM	0.3554 mL	1.7771 mL	3.5541 mL	17.7705 mL
10 mM	0.1777 mL	0.8885 mL	1.7771 mL	8.8853 mL
20 mM	0.0889 mL	0.4443 mL	0.8885 mL	4.4426 mL
50 mM	0.0355 mL	0.1777 mL	0.3554 mL	1.7771 mL
100 mM	0.0178 mL	0.0889 mL	0.1777 mL	0.8885 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc