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Cucurbitacin IIA

🥰Excellent
Catalog No. T3S1471Cas No. 58546-34-2
Alias Hemslecin A, Dihydrocucurbitacin Q1, Curcurbitacin IIA

1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a novel class of anti-cancer drug in suppression of cancer cell expansion by disrupting the actin cytoskeleton and directing the cell to undergo PARP-mediated apoptosis through the inhibition of survivin downstream of JAK2/STAT3.

Cucurbitacin IIA
Other Forms of Cucurbitacin IIA:
Hemslecin DTN5989586960-44-3
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Cucurbitacin IIA

🥰Excellent
Purity: 99.87%
Catalog No. T3S1471Alias Hemslecin A, Dihydrocucurbitacin Q1, Curcurbitacin IIACas No. 58546-34-2
1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a novel class of anti-cancer drug in suppression of cancer cell expansion by disrupting the actin cytoskeleton and directing the cell to undergo PARP-mediated apoptosis through the inhibition of survivin downstream of JAK2/STAT3.
Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
5 mg$64In Stock
10 mg$113In Stock
25 mg$213In Stock
50 mg$319In Stock
100 mg$475In Stock
500 mg$987In Stock
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Purity:99.87%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a novel class of anti-cancer drug in suppression of cancer cell expansion by disrupting the actin cytoskeleton and directing the cell to undergo PARP-mediated apoptosis through the inhibition of survivin downstream of JAK2/STAT3.
SynonymsHemslecin A, Dihydrocucurbitacin Q1, Curcurbitacin IIA
Chemical Properties
Molecular Weight562.73
FormulaC32H50O8
Cas No.58546-34-2
Smiles[H][C@@]1([C@H](O)C[C@@]2(C)[C@]3([H])CC=C4[C@@]([H])(C[C@H](O)[C@@H](O)C4(C)C)[C@]3(C)C(=O)C[C@]12C)[C@@](C)(O)C(=O)CCC(C)(C)OC(C)=O
Relative Density.1.22 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 91 mg/mL (161.71 mM), Sonication is recommended.
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7771 mL8.8853 mL17.7705 mL88.8526 mL
5 mM0.3554 mL1.7771 mL3.5541 mL17.7705 mL
10 mM0.1777 mL0.8885 mL1.7771 mL8.8853 mL
20 mM0.0889 mL0.4443 mL0.8885 mL4.4426 mL
50 mM0.0355 mL0.1777 mL0.3554 mL1.7771 mL
100 mM0.0178 mL0.0889 mL0.1777 mL0.8885 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

SurvivinInhibitorinhibitCucurbitacin IIAApoptosis
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