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Aurora kinase inhibitor-3

Name: Aurora kinase inhibitor-3
Brand: TargetMol
SKU: T5524
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5524Cas No. 879127-16-9

Alias Aurora Kinase Inhibitor III

Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR.

Aurora kinase inhibitor-3

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Purity: 98.91%

Catalog No. T5524Alias Aurora Kinase Inhibitor IIICas No. 879127-16-9

Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
2 mg	$96	In Stock	In Stock
5 mg	$163	In Stock	In Stock
10 mg	$263	In Stock	In Stock
25 mg	$446	In Stock	In Stock
50 mg	$645	In Stock	In Stock
100 mg	$886	In Stock	In Stock
200 mg	$1,220	-	In Stock
1 mL x 10 mM (in DMSO)	$179	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.91%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Aurora kinase inhibitor-3 AI Summary

Aurora kinase inhibitor-3 shows bioactivity as an inhibitor of Aurora-A kinase with an IC50 value of 42.0 nM and displays bioactivity against multiple other protein kinases, including Lck, Bmx, IGF1R, and Syk, each with varying IC50 values. It also has no significant inhibitory effect on EGFR, with an IC50 value greater than 10,000.0 nM. The compound stabilizes various proteins such as CAMK1D, PIM1, PIM2, RSK2a, and SLK, as demonstrated by thermal melting changes in assays. Additionally, it inhibits human recombinant PKR autophosphorylation in the presence of poly[I:C] with an IC50 value of 20,000.0 nM. Cell viability assays reveal that Aurora kinase inhibitor-3 decreases growth rates significantly in human fibroblasts, whereas it has mixed effects on U2OS and HEK293T cells. The compound shows differential effects on protein stability across various domains, influencing protein structure and function depending on the specific targeted region..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR.
Targets&IC50	Aurora A:42 nM
Synonyms	Aurora Kinase Inhibitor III

Chemical Properties

Molecular Weight	413.4
Formula	C₂₁H₁₈F₃N₅O
Cas No.	879127-16-9
Smiles	FC(F)(F)c1cccc(Nc2ccnc(Nc3cccc(NC(=O)C4CC4)c3)n2)c1
Relative Density.	1.456 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (120.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4190 mL	12.0948 mL	24.1896 mL	120.9482 mL
5 mM	0.4838 mL	2.4190 mL	4.8379 mL	24.1896 mL
10 mM	0.2419 mL	1.2095 mL	2.4190 mL	12.0948 mL
20 mM	0.1209 mL	0.6047 mL	1.2095 mL	6.0474 mL
50 mM	0.0484 mL	0.2419 mL	0.4838 mL	2.4190 mL
100 mM	0.0242 mL	0.1209 mL	0.2419 mL	1.2095 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc